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Rusc2 Gene Detail
Summary
  • Symbol
    Rusc2
  • Name
    RUN and SH3 domain containing 2
  • Synonyms
    mKIAA0375
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140371
    NCBI Gene: 100213
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43381979-43427088 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    918 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140371
protein coding gene Chr4:43381979-43427092 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028203
protein coding gene Chr4:41484975-41535949 (+)
A/J MGP_AJ_G0028159
protein coding gene Chr4:40020167-40064739 (+)
AKR/J MGP_AKRJ_G0028111
protein coding gene Chr4:40933486-40978656 (+)
BALB/cJ MGP_BALBcJ_G0028179
protein coding gene Chr4:40109975-40155223 (+)
C3H/HeJ MGP_C3HHeJ_G0027901
protein coding gene Chr4:41554314-41601096 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028620
protein coding gene Chr4:43022606-43069903 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025932
protein coding gene Chr4:37471802-37518261 (+)
CAST/EiJ MGP_CASTEiJ_G0027341
protein coding gene Chr4:41060699-41107646 (+)
CBA/J MGP_CBAJ_G0027867
protein coding gene Chr4:44358944-44404082 (+)
DBA/2J MGP_DBA2J_G0028016
protein coding gene Chr4:39930079-39975243 (+)
FVB/NJ MGP_FVBNJ_G0027983
protein coding gene Chr4:39148657-39194569 (+)
LP/J MGP_LPJ_G0028115
protein coding gene Chr4:41547030-41593607 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028007
protein coding gene Chr4:47619455-47666720 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028656
protein coding gene Chr4:41123706-41168803 (+)
PWK/PhJ MGP_PWKPhJ_G0027067
protein coding gene Chr4:39967497-40021676 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026893
protein coding gene Chr4:40689564-40735511 (+)
WSB/EiJ MGP_WSBEiJ_G0027421
protein coding gene Chr4:41027817-41074479 (+)



Homology
more
  • Human Ortholog
    RUSC2, RUN and SH3 domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RUSC2, RUN and SH3 domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Iporin, MRT61
  • Links
    NCBI Gene ID: 9853
    neXtProt AC: NX_Q8N2Y8
    UniProt: Q8N2Y8

  • Chr Location
    9p13.3; chr9:35487999-35561898 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18967
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RUSC2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human RUSC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035969 Ensembl Gene Model | MGI Sequence Detail 45110 C57BL/6J ±  kb
transcript ENSMUST00000035645 Ensembl | MGI Sequence Detail 5300 Not Applicable  
polypeptide ENSMUSP00000038379 Ensembl | MGI Sequence Detail 1523 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 103
    cDNA 103

    Microarray probesets 4
References
more
  • Summaries
    All 31
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory