About   Help   FAQ
Phactr4 Gene Detail
Summary
  • Symbol
    Phactr4
  • Name
    phosphatase and actin regulator 4
  • Synonyms
    3110001B12Rik, C330013F19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140327
    NCBI Gene: 100169
Location & Maps
more
  • Sequence Map
    Chr4:132355923-132422489 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66567 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 65.24 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PHACTR4, phosphatase and actin regulator 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PHACTR4, phosphatase and actin regulator 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPP1R124
  • Links
    NCBI Gene ID: 65979
    neXtProt AC: NX_Q8IZ21

  • Chr Location
    1p35.3; chr1:28369582-28500369 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    53
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    46
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Phactr4
  • Incidental Mutations
Mice homozygous for a null allele exhibit embryonic and neonatal lethality, exencephaly, neural tube defects, coloboma, and altered cell cycles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009635 VEGA Gene Model | MGI Sequence Detail 66567 C57BL/6J ±  kb
transcript OTTMUST00000022201 VEGA | MGI Sequence Detail 2349 Not Applicable  
polypeptide OTTMUSP00000010124 VEGA | MGI Sequence Detail 704 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    717 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 5
Other
Accession IDs
less
MGI:1917603, MGI:2140580, MGI:2140711
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:48268 Kasarskis A, et al., A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7485-90
  • Latest
    J:192507 Kim JY, et al., Different expression patterns of Phactr family members in normal and injured mouse brain. Neuroscience. 2012 Sep 27;221:37-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory