About   Help   FAQ
Pafah2
Gene Detail
 Symbol
Name
ID
Pafah2
platelet-activating factor acetylhydrolase 2
MGI:2140321
Synonyms 2310074E22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
66.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:134396320-134427413 bp, + strand
From VEGA annotation of GRCm38

  31094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37309  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: PAF acetylhydrolase
Gene Tree: Pafah2

Human
homologs
Human Homolog PAFAH2, platelet-activating factor acetylhydrolase 2, 40kDa
NCBI Gene ID 5051
neXtProt AC  NX_Q99487
Human Synonyms  HSD-PLA2
Human Chr (Location)  1p36; chr1:25959767-25998172 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(16) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased sensitivity to hepatic injury.
 
Interactions
Pafah2 interacts with 218 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process lipid catabolic process, lipid metabolic process, ...
Component cytoplasm
Function 1-alkyl-2-acetylglycerophosphocholine esterase activity, hydrolase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (2)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010831 (Evidence)
Ensembl Gene ModelENSMUSG00000037366 (Evidence)
Entrez Gene100163 (Evidence)
UniGene22116
DFCITC1577597, TC1654364, TC1717663
DoTSDT.101261766, DT.101277196, DT.110832824, DT.110832845, DT.111070908, DT.488776
EC3.1.1.47
Consensus CDS ProjectCCDS18771.1, CCDS71490.1
International Mouse Knockout Project StatusPafah2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010831 VEGA Gene Model | MGI Sequence Detail 31094 C57BL/6J ±  kb
transcript OTTMUST00000025331 VEGA | MGI Sequence Detail 3180 Not Applicable 
polypeptide OTTMUSP00000011619 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(14) UniProt(5)
Polymorphisms SNPs within 2kb(419 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016715 PAF acetylhydrolase
InterPro IPR005065 Platelet-activating factor acetylhydrolase
Protein Ontology PR:000012230 platelet-activating factor acetylhydrolase 2, cytoplasmic
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(34)
Other
accession IDs
MGI:1919176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory