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AI481877 Gene Detail
Summary
  • Symbol
    AI481877
  • Name
    expressed sequence AI481877
  • Synonyms
    Gm426, LOC242489, Shoc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140313
    NCBI Gene: 100155
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:59041984-59113971 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 32.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    329 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140313
protein coding gene Chr4:59041984-59138983 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028333
protein coding gene Chr4:57915947-57989541 (-)
A/J MGP_AJ_G0028294
protein coding gene Chr4:55692366-55761318 (-)
AKR/J MGP_AKRJ_G0028243
protein coding gene Chr4:57256936-57328865 (-)
BALB/cJ MGP_BALBcJ_G0028313
protein coding gene Chr4:55869885-55940415 (-)
C3H/HeJ MGP_C3HHeJ_G0028034
protein coding gene Chr4:57718432-57790458 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028754
protein coding gene Chr4:59956787-60059654 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026060
protein coding gene Chr4:52438264-52506024 (-)
CAST/EiJ MGP_CASTEiJ_G0027472
protein coding gene Chr4:57497655-57575181 (-)
CBA/J MGP_CBAJ_G0027999
protein coding gene Chr4:61987279-62063973 (-)
DBA/2J MGP_DBA2J_G0028149
protein coding gene Chr4:55603831-55675863 (-)
FVB/NJ MGP_FVBNJ_G0028116
protein coding gene Chr4:54809375-54879600 (-)
LP/J MGP_LPJ_G0028248
protein coding gene Chr4:58015324-58087620 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028140
protein coding gene Chr4:65112180-65187424 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028790
protein coding gene Chr4:57440980-57510676 (-)
PWK/PhJ MGP_PWKPhJ_G0027197
protein coding gene Chr4:55616954-55696053 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027025
protein coding gene Chr4:56774803-56849584 (-)
WSB/EiJ MGP_WSBEiJ_G0027550
protein coding gene Chr4:57423354-57493550 (-)



Homology
more
  • Human Ortholog
    SHOC1, shortage in chiasmata 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SHOC1, shortage in chiasmata 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C9orf84, ZIP2, ZIP2H
  • Links
    NCBI Gene ID: 158401
    neXtProt AC: NX_Q5VXU9
    UniProt: Q5VXU9

  • Chr Location
    9q31.3; chr9:111686175-111795949 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E9.5. Male mice homozygous for a hypomorphic allele exhibit a lack of spermatozoa, reduced testis weight and size, increased male germ cell apoptosis, and abnormal male meiosis with defective chiasmata formation and chromosomal synapsis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100155 NCBI Gene Model | MGI Sequence Detail 71988 C57BL/6J ±  kb
transcript AK135748 GenBank | EMBL | DDBJ | MGI Sequence Detail 2341 C57BL/6J  
polypeptide A2ALV5 UniProt | EBI | MGI Sequence Detail 1481 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685272
References
more
  • Summaries
    All 22
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:262079 Guiraldelli MF, et al., SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis. PLoS Genet. 2018 May;14(5):e1007381

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory