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Tdrd7
Gene Detail
 Symbol
Name
ID
Tdrd7
tudor domain containing 7
MGI:2140279
Synonyms 5730495N10Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
24.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:45965334-46034761 bp, + strand
From VEGA annotation of GRCm38

  69428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8618  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tdrd7

Human
homologs
Human Homolog TDRD7, tudor domain containing 7
NCBI Gene ID 23424
neXtProt AC  NX_Q8NHU6
Human Synonyms  CATC4, CTRCT36, PCTAIRE2BP, TRAP
Human Chr (Location)  9q22.33; chr9:97412020-97496125 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TDRD7
Alleles
and
phenotypes
All alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes arrest of spermatogenesis, male sterility, glaucoma, and cataracts. Aging mice homozygous for an ENU-induced (null) allele show additional ocular phenotypes including an enlarged anterior chamber, lens extrusion, a flat iris, uveitis, and optic neuropathy.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell differentiation, germ cell development, ...
Component chromatoid body, cytoplasm, ...
Function mRNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (31)    Tissues (27)    Images (6)
Theiler Stages: 21, 23, 24, 28
Assay TypeResults
RNA in situ 29
RT-PCR 2
cDNA source data(87)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(88) cDNA(87) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000006834 (Evidence)
Ensembl Gene ModelENSMUSG00000035517 (Evidence)
Entrez Gene100121 (Evidence)
UniGene275413
DFCITC1575747, TC1723857
DoTSDT.101130092, DT.110838166, DT.110838199, DT.40176170
NIA Mouse Gene IndexU004280
PDB2LH9, 2LY1, 2LY2
Consensus CDS ProjectCCDS18142.1, CCDS71381.1
International Mouse Knockout Project StatusTdrd7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006834 VEGA Gene Model | MGI Sequence Detail 69428 C57BL/6J ±  kb
transcript OTTMUST00000015794 VEGA | MGI Sequence Detail 3655 Not Applicable 
polypeptide OTTMUSP00000007258 VEGA | MGI Sequence Detail 1119 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(386 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025605 OST-HTH/LOTUS domain
InterPro IPR002999 Tudor domain
Protein Ontology PR:000029784 tudor domain-containing protein 7
References (Earliest) J:68708 Hrabe de Angelis MH, et al., Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug;25(4):444-7
(Latest) J:173550 Tanaka T, et al., Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10579-84
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory