About   Help   FAQ
Tdrd7 Gene Detail
Summary
  • Symbol
    Tdrd7
  • Name
    tudor domain containing 7
  • Synonyms
    5730495N10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140279
    NCBI Gene: 100121
  • Gene Overview
    MyGene.info: TDRD7
Location & Maps
more
  • Sequence Map
    Chr4:45965334-46034761 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69428 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TDRD7, tudor domain containing 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TDRD7, tudor domain containing 7
    Orthology source: HomoloGene
  • Synonyms
    CATC4, PCTAIRE2BP, TRAP
  • Links
    NCBI Gene ID: 23424
    neXtProt AC: NX_Q8NHU6

  • Chr Location
    9q22.33; chr9:97411989-97496125 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8618
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TDRD7
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TDRD7 associations

Human Disease Mouse Models
       Cataract 36; CTRCT36   OMIM: 613887
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
Homozygous inactivation of this gene causes arrest of spermatogenesis, male sterility, glaucoma, and cataracts. Aging mice homozygous for an ENU-induced (null) allele show additional ocular phenotypes including an enlarged anterior chamber, lens extrusion, a flat iris, uveitis, and optic neuropathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006834 VEGA Gene Model | MGI Sequence Detail 69428 C57BL/6J ±  kb
transcript OTTMUST00000015794 VEGA | MGI Sequence Detail 3655 Not Applicable  
polypeptide OTTMUSP00000007258 VEGA | MGI Sequence Detail 1119 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    379 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 88
    cDNA 87
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:68708 Hrabe de Angelis MH, et al., Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug;25(4):444-7
  • Latest
    J:173550 Tanaka T, et al., Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10579-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory