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Mexis Gene Detail
Summary
  • Symbol
    Mexis
  • Name
    macrophage expressed LXRa(NR1H3)-dependent amplifier of Abca1 transcription lncRNA
  • Synonyms
    AI427809, LOC381524
  • Feature Type
    lncRNA gene
  • IDs
    MGI:2140270
    NCBI Gene: 381524
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:53261356-53270232 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 28.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140270
lncRNA gene Chr4:53261356-53270232 (-)
129S1/SvImJ MGP_129S1SvImJ_G0006424
lincRNA gene Chr4:51883726-51892602 (-)
A/J MGP_AJ_G0006416
lincRNA gene Chr4:49893113-49901987 (-)
AKR/J MGP_AKRJ_G0006390
lincRNA gene Chr4:51259587-51268463 (-)
BALB/cJ MGP_BALBcJ_G0006390
lincRNA gene Chr4:50079816-50088690 (-)
C3H/HeJ MGP_C3HHeJ_G0006340
lincRNA gene Chr4:51812135-51821007 (-)
C57BL/6NJ MGP_C57BL6NJ_G0006556
lincRNA gene Chr4:53799844-53808720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0005843
lincRNA gene Chr4:46865474-46874346 (-)
CAST/EiJ MGP_CASTEiJ_G0006274
lincRNA gene Chr4:51460821-51469597 (-)
CBA/J MGP_CBAJ_G0006323
lincRNA gene Chr4:55620675-55629541 (-)
DBA/2J MGP_DBA2J_G0006345
lincRNA gene Chr4:49874885-49883759 (-)
FVB/NJ MGP_FVBNJ_G0006367
lincRNA gene Chr4:49099893-49108769 (-)
LP/J MGP_LPJ_G0006426
lincRNA gene Chr4:51988429-51997305 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0006354
lincRNA gene Chr4:58871366-58880242 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0006560
lincRNA gene Chr4:51494934-51503804 (-)
PWK/PhJ MGP_PWKPhJ_G0006210
lincRNA gene Chr4:49826920-49835763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0006123
lincRNA gene Chr4:50786062-50794774 (-)
WSB/EiJ MGP_WSBEiJ_G0006319
lincRNA gene Chr4:51395025-51403901 (-)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout affects macrophage cholesterol metabolism and increases atherosclerosis susceptibility in mice fed Western diet.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic 381524 NCBI Gene Model | MGI Sequence Detail 8877 C57BL/6J ±  kb
transcript NR_033140 RefSeq | MGI Sequence Detail 2123 C57BL/6  
polypeptide Q3TAG4 UniProt | EBI | MGI Sequence Detail 104 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 1
Other
Accession IDs
less
MGI:2686505
References
more
  • Summaries
    All 14
    Phenotypes 1
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:264834 Sallam T, et al., Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018 Mar;24(3):304-312

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory