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Ecpas Gene Detail
Summary
  • Symbol
    Ecpas
  • Name
    Ecm29 proteasome adaptor and scaffold
  • Synonyms
    AI314180, mKIAA0368
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140220
    NCBI Gene: 230249
  • Gene Overview
    MyGene.info: ECPAS
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:58798911-58912749 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 32.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140220
 protein coding gene Chr4:58797234-58917748 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028327
 protein coding gene Chr4:57664937-57784415 (-)
A/J MGP_AJ_G0028288
 protein coding gene Chr4:55442104-55561647 (-)
AKR/J MGP_AKRJ_G0028237
 protein coding gene Chr4:57005551-57128022 (-)
BALB/cJ MGP_BALBcJ_G0028307
 protein coding gene Chr4:55621556-55739569 (-)
C3H/HeJ MGP_C3HHeJ_G0028028
 protein coding gene Chr4:57467209-57587493 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028748
 protein coding gene Chr4:59697016-59813296 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026054
 protein coding gene Chr4:52189807-52306714 (-)
CAST/EiJ MGP_CASTEiJ_G0027466
 protein coding gene Chr4:57238405-57358386 (-)
CBA/J MGP_CBAJ_G0027993
 protein coding gene Chr4:61730172-61851414 (-)
DBA/2J MGP_DBA2J_G0028143
 protein coding gene Chr4:55353564-55471287 (-)
FVB/NJ MGP_FVBNJ_G0028110
 protein coding gene Chr4:54564141-54680718 (-)
LP/J MGP_LPJ_G0028242
 protein coding gene Chr4:57752743-57874951 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028134
 protein coding gene Chr4:64844958-64977317 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028784
 protein coding gene Chr4:57193344-57309415 (-)
PWK/PhJ MGP_PWKPhJ_G0027191
 protein coding gene Chr4:55372092-55487252 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027019
 protein coding gene Chr4:56518036-56631365 (-)
WSB/EiJ MGP_WSBEiJ_G0027544
 protein coding gene Chr4:57160174-57280857 (-)



Homology
more
  • Human Ortholog
    ECPAS, Ecm29 proteasome adaptor and scaffold
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ECPAS, Ecm29 proteasome adaptor and scaffold
  • Synonyms
    ECM29, KIAA0368
  • Links
    NCBI Gene ID: 23392
    UniProt: Q5VYK3

  • Chr Location
    9q31.3; chr9:111360693-111484745 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased susceptibility to chemically-induced convulsive seizures, and maturing neurons show a delay in GABAergic response switch and accelerated axon initial segment developmental positioning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    672
  • cDNA Data
    14
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050812 Ensembl Gene Model | MGI Sequence Detail 113839 C57BL/6J ±  kb
    transcript ENSMUST00000102889 Ensembl | MGI Sequence Detail 7045 Not Applicable  
    polypeptide ENSMUSP00000099953 Ensembl | MGI Sequence Detail 1840 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2140605, MGI:2140642
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:282974 Lee M, et al., Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. J Cell Biol. 2020 Feb 3;219(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/19/2021
    MGI 6.17     		The Jackson Laboratory