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Slc9b2 Gene Detail
Summary
  • Symbol
    Slc9b2
  • Name
    solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
  • Synonyms
    C80638, NHA2, nha-oc, NHE10, Nhedc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140077
    NCBI Gene: 97086
Location & Maps
more
  • Sequence Map
    Chr3:135307700-135345387 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37688 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 62.55 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC9B2, solute carrier family 9 member B2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC9B2, solute carrier family 9 member B2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NHA2, NHE10, NHEDC2
  • Links
    NCBI Gene ID: 133308
    neXtProt AC: NX_Q86UD5

  • Chr Location
    4q24; chr4:103020230-103077371 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    48
  • Chemically induced (other)
    1
  • Gene trapped
    40
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Slc9b2
  • Incidental Mutations
    APF
Mice homozygous for a gene trapped allele are viable and overtly normal, with no detectable abnormalities in osteoclast differentiation and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030292 VEGA Gene Model | MGI Sequence Detail 37688 C57BL/6J ±  kb
transcript OTTMUST00000074990 VEGA | MGI Sequence Detail 4818 Not Applicable  
polypeptide OTTMUSP00000039236 VEGA | MGI Sequence Detail 547 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    447 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011198 mitochondrial sodium/hydrogen exchanger NHA2
  • InterPro Domains
    IPR006153 Cation/H+ exchanger
    IPR030187 Mitochondrial Na(+)/H(+) exchanger NHA2
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory