Isg20l2 MGI Mouse Gene Detail - MGI:2140076 - interferon stimulated exonuclease gene 20-like 2

Symbol

Isg20l2
Name

interferon stimulated exonuclease gene 20-like 2

Feature Type

protein coding gene
IDs

MGI:2140076
NCBI Gene: 229504
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:87837621-87847993 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.78 cM
Mapping Data

1 experiment

SNPs within 2kb

40 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140076	protein coding gene	Chr3:87837602-87847994 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027375	protein coding gene	Chr3:88061645-88072004 (+)
A/J	MGP_AJ_G0027339	protein coding gene	Chr3:85072860-85083784 (+)
AKR/J	MGP_AKRJ_G0027305	protein coding gene	Chr3:87166626-87176979 (+)
BALB/cJ	MGP_BALBcJ_G0027348	protein coding gene	Chr3:85167198-85177575 (+)
C3H/HeJ	MGP_C3HHeJ_G0027091	protein coding gene	Chr3:87436588-87447615 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027794	protein coding gene	Chr3:91303916-91315274 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025147	protein coding gene	Chr3:80694938-80706750 (+)
CAST/EiJ	MGP_CASTEiJ_G0030419	protein coding gene	Chr6:131422842-131425286 (-)
CBA/J	MGP_CBAJ_G0027066	protein coding gene	Chr3:94392273-94402548 (+)
DBA/2J	MGP_DBA2J_G0027202	protein coding gene	Chr3:84564504-84574876 (+)
FVB/NJ	MGP_FVBNJ_G0027171	protein coding gene	Chr3:82837183-82847527 (+)
LP/J	MGP_LPJ_G0027310	protein coding gene	Chr3:89023718-89036216 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027190	protein coding gene	Chr3:100641674-100651924 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027852	protein coding gene	Chr3:86914521-86929573 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0026088	protein coding gene	Chr3:86100604-86112491 (+)
WSB/EiJ	MGP_WSBEiJ_G0026617	protein coding gene	Chr3:87278163-87289435 (+)

Human Ortholog

ISG20L2, interferon stimulated exonuclease gene 20 like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ISG20L2, interferon stimulated exonuclease gene 20 like 2
Synonyms

HSD38
Links

HGNC:25745

NCBI Gene ID: 81875

neXtProt AC: NX_Q9H9L3

UniProt: Q9H9L3
Chr Location

1q23.1; chr1:156721891-156728766 (-) GRCh38

MGI Vertebrate Homology

Isg20l2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ISG20L2
Gene Tree

Isg20l2

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References

1 with disease annotations

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Isg20l2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

11
cDNA Data

30
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase isg20l2

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All Sequences

41
RefSeq

4
UniProt

4
CCDS

CCDS17459.1

Ensembl

ENSMUSG00000048039 (Evidence)
NCBI Gene

229504

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048039	Ensembl Gene Model \| MGI Sequence Detail	10373	C57BL/6J	± kb
transcript	ENSMUST00000055984	Ensembl \| MGI Sequence Detail	2893	Not Applicable
polypeptide	ENSMUSP00000059783	Ensembl \| MGI Sequence Detail	368	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009115 interferon-stimulated 20 kDa exonuclease-like 2

(term hierarchy)
EC

3.1.-.-
InterPro Domains

IPR013520 Exonuclease, RNase T/DNA polymerase III

IPR037433 ISG20, DEDDh 3'-5' exonuclease domain

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

IPR047021 RNA exonuclease REXO1/REXO3/REXO4-like

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All nucleic 30

cDNA 30

Microarray probesets 4

Summaries

All 34

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Isg20l2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29869	Chr3:87837511-87837541 (+)	-95 bp
Tssr29870	Chr3:87837563-87837657 (+)	-11 bp
Tssr29871	Chr3:87837744-87837756 (+)	129 bp
Tssr29872	Chr3:87837823-87837907 (+)	244 bp
Tssr29873	Chr3:87839472-87839491 (+)	1,861 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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