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Spg20
Gene Detail
 Symbol
Name
ID
Spg20
spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)
MGI:2139806
Synonyms mKIAA0610, TAHCCP1
Feature Type protein coding gene
Genetic Map
Chromosome 3
26.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:55112108-55137322 bp, + strand
From VEGA annotation of GRCm38

  25215 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Spg20

Human
homologs
Human Homolog SPG20, spastic paraplegia 20 (Troyer syndrome)
NCBI Gene ID 23111
neXtProt AC  NX_Q8N0X7
Human Synonyms  SPARTIN, TAHCCP1
Human Chr (Location)  13q13.3; chr13:36301638-36370180 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SPG20
Alleles
and
phenotypes
All alleles(9) : Targeted(7) Gene trapped(2)
 
Mice homozygous for a knock-out allele exhibit impaired lipid droplet amintenance, cytokinesis and impaired motor coordination.
 
Human Diseases Modeled Using Mouse Spg20 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process abscission, adipose tissue development, ...
Component cytoplasm, lipid particle, ...
Function protein binding, ubiquitin protein ligase binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (3)    Images (19)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(112)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(112) cDNA(112)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026686 (Evidence)
Ensembl Gene ModelENSMUSG00000036580 (Evidence)
Entrez Gene229285 (Evidence)
UniGene235523
DFCITC1572674, TC1597243, TC1607872
DoTSDT.101738410, DT.101738411, DT.488250, DT.97346371
NIA Mouse Gene IndexU003243
Consensus CDS ProjectCCDS38432.1, CCDS50908.1
International Mouse Knockout Project StatusSpg20
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026686 VEGA Gene Model | MGI Sequence Detail 25215 C57BL/6J ±  kb
transcript OTTMUST00000066033 VEGA | MGI Sequence Detail 3981 Not Applicable 
polypeptide OTTMUSP00000033005 VEGA | MGI Sequence Detail 671 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(188 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007330 MIT
InterPro IPR009686 Senescence/spartin-associated
Protein Ontology PR:000015518 spartin
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:190122 Cobanoglu G, et al., Are alsin and spartin novel interaction partners?. Biochem Biophys Res Commun. 2012 Oct 12;427(1):1-4
All references(39)
Other
accession IDs
MGI:2140061

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory