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Clca4b Gene Detail
Summary
  • Symbol
    Clca4b
  • Name
    chloride channel accessory 4B
  • Synonyms
    AI747448
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139790
    NCBI Gene: 99709
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:144616682-144638290 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 69.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139790
protein coding gene Chr3:144616682-144638290 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027955
protein coding gene Chr3:148228648-148249947 (-)
A/J MGP_AJ_G0027914
protein coding gene Chr3:143021613-143043611 (-)
AKR/J MGP_AKRJ_G0027880
protein coding gene Chr3:146803620-146830363 (-)
BALB/cJ MGP_BALBcJ_G0027926
protein coding gene Chr3:142823658-142861076 (-)
C3H/HeJ MGP_C3HHeJ_G0027656
protein coding gene Chr3:147170390-147194251 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0025707
protein coding gene Chr3:138032539-138057125 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0027771
protein coding gene Chr3:142173960-142199131 (-)
FVB/NJ MGP_FVBNJ_G0027737
protein coding gene Chr3:139582170-139608898 (-)
LP/J MGP_LPJ_G0027881
protein coding gene Chr3:149643692-149669874 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027770
protein coding gene Chr3:167043593-167108562 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028427
protein coding gene Chr3:146396197-146432182 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CLCA4, chloride channel accessory 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLCA4, chloride channel accessory 4
  • Synonyms
    CaCC, CaCC2
  • Links
    NCBI Gene ID: 22802
    neXtProt AC: NX_Q14CN2
    UniProt: Q14CN2

  • Chr Location
    1p22.3; chr1:86547078-86580754 (+)  GRCh38

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
No notable phenotype was detected in a high throughput screen of homozyogus mutant null mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 99709 NCBI Gene Model | MGI Sequence Detail 21609 C57BL/6J ±  kb
transcript NM_001033199 RefSeq | MGI Sequence Detail 2997 C57BL/6  
polypeptide NP_001028371 RefSeq | MGI Sequence Detail 925 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR013642 Calcium-activated chloride channel, N-terminal
    IPR004727 Calcium-activated chloride channel protein, chordata
    IPR013783 Immunoglobulin-like fold
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 21
    Diseases 1
    Gene Ontology 1
    Phenotypes 7
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory