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Sec24b Gene Detail
Summary
  • Symbol
    Sec24b
  • Name
    SEC24 homolog B, COPII coat complex component
  • Synonyms
    SEC24
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139764
    NCBI Gene: 99683
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129776408-129855202 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 59.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1927 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139764
 protein coding gene Chr3:129776408-129855248 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027879
 protein coding gene Chr3:132690502-132775484 (-)
A/J MGP_AJ_G0027837
 protein coding gene Chr3:128055170-128132307 (-)
AKR/J MGP_AKRJ_G0027802
 protein coding gene Chr3:131375471-131456018 (-)
BALB/cJ MGP_BALBcJ_G0027850
 protein coding gene Chr3:127899484-127979581 (-)
C3H/HeJ MGP_C3HHeJ_G0027579
 protein coding gene Chr3:131772460-131854917 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028294
 protein coding gene Chr3:137416195-137499356 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025632
 protein coding gene Chr3:123590338-123664702 (-)
CAST/EiJ MGP_CASTEiJ_G0027036
 protein coding gene Chr3:131457257-131540737 (-)
CBA/J MGP_CBAJ_G0027555
 protein coding gene Chr3:142042091-142127779 (-)
DBA/2J MGP_DBA2J_G0027696
 protein coding gene Chr3:127251016-127329443 (-)
FVB/NJ MGP_FVBNJ_G0027663
 protein coding gene Chr3:124840374-124919824 (-)
LP/J MGP_LPJ_G0027805
 protein coding gene Chr3:134188372-134273815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027694
 protein coding gene Chr3:149998309-150090337 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028351
 protein coding gene Chr3:131048430-131124889 (-)
PWK/PhJ MGP_PWKPhJ_G0026760
 protein coding gene Chr3:126991138-127069310 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026585
 protein coding gene Chr3:129117963-129192337 (-)
WSB/EiJ MGP_WSBEiJ_G0027115
 protein coding gene Chr3:131769114-131848639 (-)



Homology
more
  • Human Ortholog
    SEC24B, SEC24 homolog B, COPII component
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC24B, SEC24 homolog B, COPII component
  • Synonyms
    SEC24
  • Links
    NCBI Gene ID: 10427
    UniProt: O95487

  • Chr Location
    4q25; chr4:109433602-109540896 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU induced mutation exhibit craniorachischisis, abnormal embryo shape, omphalocele, disoriented hair cells, and failure of eyelid fusion.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    152
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001052 Ensembl Gene Model | MGI Sequence Detail 78795 C57BL/6J ±  kb
    transcript ENSMUST00000001079 Ensembl | MGI Sequence Detail 5128 Not Applicable  
    polypeptide ENSMUSP00000001079 Ensembl | MGI Sequence Detail 1251 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR029006 ADF-H/Gelsolin-like domain superfamily
      IPR007123 Gelsolin-like domain
      IPR036180 Gelsolin-like domain superfamily
      IPR012990 Sec23/Sec24 beta-sandwich
      IPR050550 SEC23/SEC24 family, SEC24 subfamily
      IPR006900 Sec23/Sec24, helical domain
      IPR036175 Sec23/Sec24 helical domain superfamily
      IPR006896 Sec23/Sec24, trunk domain
      IPR041742 Sec24-like, trunk domain
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR006895 Zinc finger, Sec23/Sec24-type
      IPR036174 Zinc finger, Sec23/Sec24-type superfamily
    • GlyGen
      Q80ZX0 4 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 152
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Diseases 1
      Phenotypes 20
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/09/2026
    MGI 6.24     		The Jackson Laboratory