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Clca2 Gene Detail
Summary
  • Symbol
    Clca2
  • Name
    chloride channel accessory 2
  • Synonyms
    Clca5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139758
    NCBI Gene: 229933
  • Gene Overview
    MyGene.info: CLCA2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:145070263-145099443 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29181 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 69.31 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CLCA2, chloride channel accessory 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CLCA2, chloride channel accessory 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CACC, CaCC-3, CACC3, CLCRG2
  • Links
    NCBI Gene ID: 9635
    neXtProt AC: NX_Q9UQC9
    UniProt: Q9UQC9

  • Chr Location
    1p22.3; chr1:86424086-86456558 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit increases in liver weight to body weight ratio and hepatocyte hypertrophy; one incidence of multifocal hepatic necrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000055186 VEGA Gene Model | MGI Sequence Detail 29181 C57BL/6J ±  kb
    transcript OTTMUST00000136666 VEGA | MGI Sequence Detail 3986 Not Applicable  
    polypeptide OTTMUSP00000072100 VEGA | MGI Sequence Detail 942 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      290 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005524 calcium-activated chloride channel regulator 2
    • EC
    • InterPro Domains
      IPR013642 Calcium-activated chloride channel, N-terminal
      IPR004727 Calcium-activated chloride channel protein, chordata
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 4
      Phenotypes 3
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:261946 Seltmann K, et al., Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress. Sci Transl Med. 2018 May 9;10(440)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory