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Clca2
Gene Detail
Symbol

Name
ID
Clca2
chloride channel calcium activated 2
MGI:2139758
Synonyms
Clca5
Feature Type
protein coding gene
Genetic Map
Chromosome 3
69.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:145070265-145099104 bp, - strand
From Ensembl annotation of GRCm38

  28840 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4765  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: calcium-activated chloride channel
Gene Tree: Clca2

Human
homologs
Human Homolog CLCA2, chloride channel accessory 2
NCBI Gene ID 9635
neXtProt AC  NX_Q9UQC9
Human Synonyms  CACC, CaCC-3, CACC3, CLCRG2
Human Chr (Location)  1p22.3; chr1:86424086-86456558 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit increases in liver weight to body weight ratio and hepatocyte hypertrophy; one incidence of multifocal hepatic necrosis.
 
Interactions
Clca2 interacts with 168 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell adhesion, chloride transmembrane transport, ...
Component cell junction, integral component of membrane, ...
Function chloride channel activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (142)    Tissues (58)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 58
In situ reporter (knock in) 38
RT-PCR 46
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000036960 (Evidence)
Entrez Gene229933 (Evidence)
UniGene331420
DFCITC1584663, TC1596923
DoTSDT.91552462, DT.101709690
NIA Mouse Gene IndexU024735
EC3.4.-.-
Consensus CDS ProjectCCDS17890.1
International Mouse Knockout Project StatusClca2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036960 Ensembl Gene Model | MGI Sequence Detail 28840 C57BL/6J ±  kb
transcript ENSMUST00000040465 Ensembl | MGI Sequence Detail 3984 Not Applicable 
polypeptide ENSMUSP00000036029 Ensembl | MGI Sequence Detail 942 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(288 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004727 Calcium-activated chloride channel protein
InterPro IPR013642 Chloride channel calcium-activated
InterPro IPR015394 Domain of unknown function DUF1973
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000005524 calcium-activated chloride channel regulator 2
References
(Earliest) J:93468 Evans SR, et al., Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine. J Biol Chem. 2004 Nov 1;279(40):41792-800
(Latest) J:187011 Rajagopal M, et al., Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells. Am J Physiol Renal Physiol. 2012 Aug;303(4):F483-91
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory