Clca5
Gene Detail

Symbol Name ID

Clca5 chloride channel calcium activated 5 MGI:2139758

Feature Type

protein coding gene

Genetic Map

Chromosome 3

69.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:145070265-145099041 bp, - strand From NCBI annotation of GRCm38   28777 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Clca5 ± 2 cM)

Protein SuperFamily: calcium-activated chloride channel
Gene Tree: Clca5

Human ortholog

CLCA2 chloride channel accessory 2 NCBI Gene ID 9635
Human Synonyms: CACC, CaCC-3, CACC3, CLCRG2
Human Chr1:86889769-86922241 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a targeted null mutation exhibit increases in liver weight to body weight ratio and hepatocyte hypertrophy; one incidence of multifocal hepatic necrosis.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell adhesion, chloride transport, ...
Component	cell junction, integral to membrane, ...
Function	chloride channel activity, ligand-gated ion channel activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (142)    Tissues (58)    Images (36)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	58
In situ reporter (knock in)	38
RT-PCR	46

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000036960 (Evidence)
Entrez Gene	229933 (Evidence)
UniGene	331420
DFCI	TC1584663, TC1596923
DoTS	DT.101709690, DT.91552462
NIA Mouse Gene Index	U024735
Consensus CDS Project	CCDS17890.1
International Mouse Knockout Project Status	Clca5

Sequences

Length	Strain/Species
genomic	229933	NCBI Gene Model | MGI Sequence Detail	28777	C57BL/6J
transcript	NM_178697	RefSeq | MGI Sequence Detail	3921	C57BL/6
polypeptide	Q8BG22	UniProt | EBI | MGI Sequence Detail	942	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(270 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004727	Calcium-activated chloride channel protein
InterPro	IPR013642	Chloride channel calcium-activated
InterPro	IPR015394	Domain of unknown function DUF1973
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000005524	calcium-activated chloride channel regulator 2

Graphical View of Protein Domain Structure

References

(Earliest) J:93468 Evans SR, et al., Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine. J Biol Chem. 2004 Nov 1;279(40):41792-800
(Latest) J:187011 Rajagopal M, et al., Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells. Am J Physiol Renal Physiol. 2012 Aug;303(4):F483-91
All references(28)