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Eps8l3 Gene Detail
Summary
  • Symbol
    Eps8l3
  • Name
    EPS8-like 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139743
    NCBI Gene: 99662
  • Gene Overview
    MyGene.info: EPS8L3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107877229-107892900 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139743
protein coding gene Chr3:107873858-107892900 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027756
protein coding gene Chr3:109393516-109410321 (+)
A/J MGP_AJ_G0027716
protein coding gene Chr3:105931795-105947520 (+)
AKR/J MGP_AKRJ_G0027681
protein coding gene Chr3:108503498-108520825 (+)
BALB/cJ MGP_BALBcJ_G0027728
protein coding gene Chr3:105622737-105639035 (+)
C3H/HeJ MGP_C3HHeJ_G0027458
protein coding gene Chr3:108848683-108866150 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028172
protein coding gene Chr3:113480006-113496519 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025510
protein coding gene Chr3:102078130-102093566 (+)
CAST/EiJ MGP_CASTEiJ_G0026914
protein coding gene Chr3:108229296-108246441 (+)
CBA/J MGP_CBAJ_G0027433
protein coding gene Chr3:117329679-117348600 (+)
DBA/2J MGP_DBA2J_G0027575
protein coding gene Chr3:105116663-105132536 (+)
FVB/NJ MGP_FVBNJ_G0027543
protein coding gene Chr3:102998010-103013662 (+)
LP/J MGP_LPJ_G0027682
protein coding gene Chr3:110814583-110830363 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027573
protein coding gene Chr3:123410211-123426688 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028227
protein coding gene Chr3:108104411-108120829 (+)
PWK/PhJ MGP_PWKPhJ_G0026640
protein coding gene Chr3:104861046-104877054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026460
protein coding gene Chr3:106234428-106250291 (+)
WSB/EiJ MGP_WSBEiJ_G0026994
protein coding gene Chr3:108624580-108640218 (+)



Homology
more
  • Human Ortholog
    EPS8L3, EPS8 like 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPS8L3, EPS8 like 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPS8R3
  • Links
    NCBI Gene ID: 79574
    neXtProt AC: NX_Q8TE67
    UniProt: Q8TE67

  • Chr Location
    1p13.3; chr1:109750080-109764022 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040600 Ensembl Gene Model | MGI Sequence Detail 15672 C57BL/6J ±  kb
    transcript ENSMUST00000037375 Ensembl | MGI Sequence Detail 2271 Not Applicable  
    polypeptide ENSMUSP00000042004 Ensembl | MGI Sequence Detail 600 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007150 epidermal growth factor receptor kinase substrate 8-like protein 3
    • InterPro Domains
      IPR033928 Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain
      IPR035462 Eps8, SH3 domain
      IPR011993 PH-like domain superfamily
      IPR001452 SH3 domain
      IPR036028 SH3-like domain superfamily
      IPR013625 Tensin/EPS8 phosphotyrosine-binding domain
    Molecular
    Reagents
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    • All nucleic 12
      cDNA 8
      Primer pair 2
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:194289 Bell SM, et al., Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory