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Golga2 Gene Detail
Summary
  • Symbol
    Golga2
  • Name
    golgi autoantigen, golgin subfamily a, 2
  • Synonyms
    GM130
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139395
    NCBI Gene: 99412
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32178299-32197925 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139395
protein coding gene Chr2:32177396-32197933 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025601
protein coding gene Chr2:30732592-30753187 (+)
A/J MGP_AJ_G0025520
protein coding gene Chr2:26834761-29450455 (+)
AKR/J MGP_AKRJ_G0025548
protein coding gene Chr2:30473879-30499305 (+)
BALB/cJ MGP_BALBcJ_G0025575
protein coding gene Chr2:29555729-29577276 (+)
C3H/HeJ MGP_C3HHeJ_G0025277
protein coding gene Chr2:27662907-30394087 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025960
protein coding gene Chr2:28831323-31691277 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023428
protein coding gene Chr2:28157824-28178657 (+)
CAST/EiJ MGP_CASTEiJ_G0024740
protein coding gene Chr2:27555585-30330055 (+)
CBA/J MGP_CBAJ_G0025313
protein coding gene Chr2:32851875-32889331 (+)
DBA/2J MGP_DBA2J_G0025446
protein coding gene Chr2:29197494-29218390 (+)
FVB/NJ MGP_FVBNJ_G0025350
protein coding gene Chr2:26434399-29091258 (+)
LP/J MGP_LPJ_G0025532
protein coding gene Chr2:30605748-30627536 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025439
protein coding gene Chr2:32519563-32544794 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026019
protein coding gene Chr2:27653331-30380612 (+)
PWK/PhJ MGP_PWKPhJ_G0024545
protein coding gene Chr2:29101971-29123165 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024345
protein coding gene Chr2:30515509-30536154 (+)
WSB/EiJ MGP_WSBEiJ_G0024866
protein coding gene Chr2:30531465-30551997 (+)



Homology
more
  • Human Ortholog
    GOLGA2, golgin A2
  • Vertebrate Orthologs
    15
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GOLGA2, golgin A2
  • Synonyms
    GM130
  • Links
    NCBI Gene ID: 2801
    neXtProt AC: NX_Q08379
    UniProt: Q08379

  • Chr Location
    9q34.11; chr9:128255829-128276007 (-)  GRCh38.p7

  • Human Ortholog
    GOLGA6A, golgin A6 family member A
  • Synonyms
    GLP, GOLGA6
  • Links
    NCBI Gene ID: 342096
    neXtProt AC: NX_Q9NYA3
    UniProt: Q9NYA3

  • Chr Location
    15q24.1; chr15:74069857-74082550 (-)  GRCh38.p7

  • Human Ortholog
    GOLGA6B, golgin A6 family member B
  • Synonyms
    GOLGA, GOLGA6D
  • Links
    NCBI Gene ID: 55889
    neXtProt AC: NX_A6NDN3
    UniProt: A6NDN3

  • Chr Location
    15q24.1; chr15:72638291-72669604 (+)  GRCh38.p7

  • Human Ortholog
    GOLGA6C, golgin A6 family member C
  • Links
    NCBI Gene ID: 653641
    neXtProt AC: NX_A6NDK9
    UniProt: A6NDK9

  • Chr Location
    15q24.2; chr15:75258404-75273455 (+)  GRCh38.p7

  • Human Ortholog
    GOLGA6D, golgin A6 family member D
  • Links
    NCBI Gene ID: 653643
    neXtProt AC: NX_P0CG33
    UniProt: P0CG33

  • Chr Location
    15q24.2; chr15:75282841-75295807 (+)  GRCh38.p7

  • Human Ortholog
    GOLGA8A, golgin A8 family member A
  • Synonyms
    CFAP286, FAP286, GM88, GOLGA8B
  • Links
    NCBI Gene ID: 23015
    neXtProt AC: NX_A7E2F4
    UniProt: A7E2F4, A8MQT2

  • Chr Location
    15q14; chr15:34379068-34437466 (-)  GRCh38.p7

  • Human Ortholog
    GOLGA8B, golgin A8 family member B
  • Synonyms
    GOLGA5
  • Links
    NCBI Gene ID: 440270
    neXtProt AC: NX_A8MQT2
    UniProt: A8MQT2

  • Chr Location
    15q14; chr15:34525276-34583651 (-)  GRCh38.p7

  • Human Ortholog
    GOLGA8H, golgin A8 family member H
  • Synonyms
    GOLGA6L11
  • Links
    NCBI Gene ID: 728498
    neXtProt AC: NX_P0CJ92
    UniProt: P0CJ92

  • Chr Location
    15q13.2; chr15:30604030-30617827 (+)  GRCh38.p7

  • Human Ortholog
    GOLGA8J, golgin A8 family member J
  • Links
    NCBI Gene ID: 653073
    neXtProt AC: NX_A6NMD2
    UniProt: A6NMD2

  • Chr Location
    15q13.2; chr15:30082627-30096711 (+)  GRCh38.p7

  • Human Ortholog
    GOLGA8K, golgin A8 family member K
  • Links
    NCBI Gene ID: 653125
    UniProt: D6RF30

  • Chr Location
    15q13.3; chr15:32389585-32403292 (-)  GRCh38.p7

  • Human Ortholog
    GOLGA8M, golgin A8 family member M
  • Links
    NCBI Gene ID: 653720
    neXtProt AC: NX_H3BSY2
    UniProt: H3BSY2

  • Chr Location
    15q13.1; chr15:28698695-28718512 (-)  GRCh38.p7

  • Human Ortholog
    GOLGA8N, golgin A8 family member N
  • Synonyms
    GOLGA8R
  • Links
    NCBI Gene ID: 643699
    neXtProt AC: NX_F8WBI6
    UniProt: F8WBI6

  • Chr Location
    15q13.3; chr15:32593456-32607310 (+)  GRCh38.p7

  • Human Ortholog
    GOLGA8O, golgin A8 family member O
  • Links
    NCBI Gene ID: 728047
    neXtProt AC: NX_A6NCC3
    UniProt: A6NCC3

  • Chr Location
    15q13.3; chr15:32441914-32456323 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display lethality before postnatal day 35, impaired postnatal growth, loss of Purkinje cells, and Golgi apparatus defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 99412 NCBI Gene Model | MGI Sequence Detail 19627 C57BL/6J ±  kb
    transcript NM_133852 RefSeq | MGI Sequence Detail 4361 C57BL/6  
    polypeptide Q921M4 UniProt | EBI | MGI Sequence Detail 999 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 115

      Microarray probesets 3
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 65
      Gene Ontology 43
      Phenotypes 9
    • Earliest
      J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
    • Latest
      J:304266 Jiang Y, et al., Loss of GM130 does not impair oocyte meiosis and embryo development in mice. Biochem Biophys Res Commun. 2020 Nov 12;532(3):336-340

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/08/2021
    MGI 6.17
    The Jackson Laboratory