Garnl3 MGI Mouse Gene Detail - MGI:2139309 - GTPase activating RANGAP domain-like 3

Symbol

Garnl3
Name

GTPase activating RANGAP domain-like 3

Feature Type

protein coding gene
IDs

MGI:2139309
NCBI Gene: 99326
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:32876236-33021666 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 22.09 cM
Mapping Data

1 experiment

SNPs within 2kb

321 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2139309	protein coding gene	Chr2:32876236-33021871 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025630	protein coding gene	Chr2:31491666-31642381 (-)
A/J	MGP_AJ_G0025607	protein coding gene	Chr2:30144561-30292442 (-)
AKR/J	MGP_AKRJ_G0025577	protein coding gene	Chr2:31225508-31372837 (-)
BALB/cJ	MGP_BALBcJ_G0025604	protein coding gene	Chr2:30265091-30412759 (-)
C3H/HeJ	MGP_C3HHeJ_G0025364	protein coding gene	Chr2:31109877-31265723 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026048	protein coding gene	Chr2:32439250-32584446 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023457	protein coding gene	Chr2:28871519-29021772 (-)
CAST/EiJ	MGP_CASTEiJ_G0024826	protein coding gene	Chr2:31074900-31231993 (-)
CBA/J	MGP_CBAJ_G0025342	protein coding gene	Chr2:33681954-33833313 (-)
DBA/2J	MGP_DBA2J_G0025475	protein coding gene	Chr2:29909019-30055504 (-)
FVB/NJ	MGP_FVBNJ_G0025437	protein coding gene	Chr2:29800958-29948408 (-)
LP/J	MGP_LPJ_G0025561	protein coding gene	Chr2:31374962-31530196 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025468	protein coding gene	Chr2:33273890-33433388 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026106	protein coding gene	Chr2:31098817-31256929 (-)
PWK/PhJ	MGP_PWKPhJ_G0024574	protein coding gene	Chr2:29822950-29971776 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024374	protein coding gene	Chr2:31263411-31418323 (-)
WSB/EiJ	MGP_WSBEiJ_G0024895	protein coding gene	Chr2:31288378-31443935 (-)

Human Ortholog

GARNL3, GTPase activating Rap/RanGAP domain like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GARNL3, GTPase activating Rap/RanGAP domain like 3
Synonyms

bA356B19.1
Links

HGNC:25425

NCBI Gene ID: 84253

neXtProt AC: NX_Q5VVW2

UniProt: Q5VVW2
Chr Location

9q33.3; chr9:127224265-127393660 (+) GRCh38

MGI Vertebrate Homology

Garnl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GARNL3
Gene Tree

Garnl3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

2
Gene trapped

12
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

52 strains or lines available

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

9
cDNA Data

28
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

91
RefSeq

35
UniProt

6
CCDS

CCDS15938.1, CCDS89476.1

Ensembl

ENSMUSG00000038860 (Evidence)
NCBI Gene

99326

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038860	Ensembl Gene Model \| MGI Sequence Detail	145431	C57BL/6J	± kb
transcript	ENSMUST00000137381	Ensembl \| MGI Sequence Detail	3551	Not Applicable
polypeptide	ENSMUSP00000122576	Ensembl \| MGI Sequence Detail	1038	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000030412 GTPase-activating Rap/Ran-GAP domain-like protein 3

(term hierarchy)
InterPro Domains

IPR001180 Citron homology (CNH) domain

IPR000331 Rap/Ran-GAP domain

IPR035974 Rap/Ran-GAP superfamily

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All nucleic 29

cDNA 29

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Garnl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23591	Chr2:33021688-33021707 (-)	-32 bp
Tssr23590	Chr2:33021657-33021670 (-)	2 bp
Tssr23589	Chr2:33020577-33020632 (-)	1,061 bp
Tssr23588	Chr2:33020478-33020491 (-)	1,181 bp
Tssr23587	Chr2:33020233-33020263 (-)	1,418 bp
Tssr23586	Chr2:32977181-32977219 (-)	44,466 bp
Tssr23585	Chr2:32976442-32976459 (-)	45,215 bp
Tssr23584	Chr2:32976279-32976296 (-)	45,378 bp
Tssr23583	Chr2:32976265-32976276 (-)	45,395 bp
Tssr23582	Chr2:32976241-32976253 (-)	45,419 bp
Tssr23581	Chr2:32976216-32976227 (-)	45,444 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23