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Snph Gene Detail
Summary
  • Symbol
    Snph
  • Name
    syntaphilin
  • Synonyms
    mKIAA0374
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139270
    NCBI Gene: 241727
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:151590549-151632593 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    264 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139270
protein coding gene Chr2:151590549-151633030 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026642
protein coding gene Chr2:156076112-156119326 (-)
A/J MGP_AJ_G0026608
protein coding gene Chr2:149868914-149910872 (-)
AKR/J MGP_AKRJ_G0026578
protein coding gene Chr2:154240570-154282462 (-)
BALB/cJ MGP_BALBcJ_G0026617
protein coding gene Chr2:150181386-150223285 (-)
C3H/HeJ MGP_C3HHeJ_G0026360
protein coding gene Chr2:154628892-154670830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027066
protein coding gene Chr2:160631136-160673676 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024437
protein coding gene Chr2:143482547-143524068 (-)
CAST/EiJ MGP_CASTEiJ_G0025821
protein coding gene Chr2:154846895-154889969 (-)
CBA/J MGP_CBAJ_G0026338
protein coding gene Chr2:166509135-166553790 (-)
DBA/2J MGP_DBA2J_G0026474
protein coding gene Chr2:149084366-149126264 (-)
FVB/NJ MGP_FVBNJ_G0026439
protein coding gene Chr2:147530967-147572955 (-)
LP/J MGP_LPJ_G0026578
protein coding gene Chr2:156247831-156291178 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026461
protein coding gene Chr2:170670585-170719184 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027121
protein coding gene Chr2:154114744-154157581 (-)
PWK/PhJ MGP_PWKPhJ_G0025555
protein coding gene Chr2:148611410-148654110 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025358
protein coding gene Chr2:152951860-152993870 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SNPH, syntaphilin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SNPH, syntaphilin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9751
    neXtProt AC: NX_O15079
    UniProt: O15079

  • Chr Location
    20p13; chr20:1266291-1309327 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with disruptions in this gene are viable, fertile, and morphologically normal. However, they do display subtile deficiencies in coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027457 Ensembl Gene Model | MGI Sequence Detail 42045 C57BL/6J ±  kb
transcript ENSMUST00000028951 Ensembl | MGI Sequence Detail 4730 Not Applicable  
polypeptide ENSMUSP00000028951 Ensembl | MGI Sequence Detail 528 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139400, MGI:2139413
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:247781 Caino MC, et al., Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017 Oct 02;127(10):3755-3769

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory