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Tm9sf4 Gene Detail
Summary
  • Symbol
    Tm9sf4
  • Name
    transmembrane 9 superfamily protein member 4
  • Synonyms
    mKIAA0255
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139220
    NCBI Gene: 99237
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:153161303-153210466 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139220
protein coding gene Chr2:153161301-153210466 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026688
protein coding gene Chr2:157774126-157825801 (+)
A/J MGP_AJ_G0026654
protein coding gene Chr2:151463228-151513732 (+)
AKR/J MGP_AKRJ_G0026624
protein coding gene Chr2:155889293-155940606 (+)
BALB/cJ MGP_BALBcJ_G0026663
protein coding gene Chr2:151773108-151824131 (+)
C3H/HeJ MGP_C3HHeJ_G0026406
protein coding gene Chr2:156260962-156318344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027112
protein coding gene Chr2:162346575-162414604 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024483
protein coding gene Chr2:145046475-145092828 (+)
CAST/EiJ MGP_CASTEiJ_G0025867
protein coding gene Chr2:156516547-156571337 (+)
CBA/J MGP_CBAJ_G0026384
protein coding gene Chr2:168329165-168382695 (+)
DBA/2J MGP_DBA2J_G0026520
protein coding gene Chr2:150672539-150721565 (+)
FVB/NJ MGP_FVBNJ_G0026486
protein coding gene Chr2:149134908-149190460 (+)
LP/J MGP_LPJ_G0026624
protein coding gene Chr2:157918597-157974403 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026507
protein coding gene Chr2:172373831-172428183 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027168
protein coding gene Chr2:155788446-155843577 (+)
PWK/PhJ MGP_PWKPhJ_G0025601
protein coding gene Chr2:150204890-150256063 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025404
protein coding gene Chr2:154622911-154672284 (+)
WSB/EiJ MGP_WSBEiJ_G0025937
protein coding gene Chr2:156685785-156738137 (+)



Homology
more
  • Human Ortholog
    TM9SF4, transmembrane 9 superfamily member 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TM9SF4, transmembrane 9 superfamily member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ836N17.2
  • Links
    NCBI Gene ID: 9777
    neXtProt AC: NX_Q92544
    UniProt: Q92544

  • Chr Location
    20q11.21; chr20:32109506-32167258 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit abnormal hair follicles and sebaceous glands, vertebrae and rib abnormalities, and increased circulating cholesterol, calcium, albumin, and total protein levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068040 Ensembl Gene Model | MGI Sequence Detail 49164 C57BL/6J ±  kb
    transcript ENSMUST00000089027 Ensembl | MGI Sequence Detail 3896 Not Applicable  
    polypeptide ENSMUSP00000086422 Ensembl | MGI Sequence Detail 643 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 139

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138821
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:264029 Sun L, et al., TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation. Cell Death Differ. 2018 Feb;25(2):368-379

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory