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Anapc2 Gene Detail
Summary
  • Symbol
    Anapc2
  • Name
    anaphase promoting complex subunit 2
  • Synonyms
    9230107K09Rik, APC2, Emi4, expressed during mesenchymal induction 4, Imi4, mKIAA1406
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139135
    NCBI Gene: 99152
  • Gene Overview
    MyGene.info: ANAPC2
Location & Maps
more
  • Sequence Map
    Chr2:25272478-25285915 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13438 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.12 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANAPC2, anaphase promoting complex subunit 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ANAPC2, anaphase promoting complex subunit 2
    Orthology source: HomoloGene
  • Synonyms
    APC2
  • Links
    NCBI Gene ID: 29882
    neXtProt AC: NX_Q9UJX6

  • Chr Location
    9q34.3; chr9:137174784-137188605 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    4
  • Targeted
    5
  • Incidental Mutations
Homozygous mutation of this gene results in embryonic lethality before E6.5. Conditional ablation in the liver results in liver failure and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011902 VEGA Gene Model | MGI Sequence Detail 13438 C57BL/6J ±  kb
transcript OTTMUST00000028080 VEGA | MGI Sequence Detail 3004 Not Applicable  
polypeptide OTTMUSP00000012722 VEGA | MGI Sequence Detail 837 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    50 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000004016 anaphase-promoting complex subunit 2
  • InterPro Domains
    IPR014786 Anaphase-promoting complex subunit 2, C-terminal
    IPR016158 Cullin homology
    IPR001373 Cullin, N-terminal
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 196
    cDNA 196

    Microarray probesets 3
Other
Accession IDs
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MGI:1927108
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:63377 Abidari JM, et al., Identification of novel genes expressed during metanephric induction through single-cell library screening. Kidney Int. 2000 Jun;57(6):2221-8
  • Latest
    J:174830 Kuczera T, et al., The anaphase promoting complex is required for memory function in mice. Learn Mem. 2011 Jan;18(1):49-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory