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Cep152 Gene Detail
Summary
  • Symbol
    Cep152
  • Name
    centrosomal protein 152
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139083
    NCBI Gene: 99100
  • Gene Overview
    MyGene.info: CEP152
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:125563088-125625113 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 61.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    625 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139083
protein coding gene Chr2:125549864-125625179 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026430
protein coding gene Chr2:128755004-128826042 (-)
A/J MGP_AJ_G0026393
protein coding gene Chr2:123515213-123580436 (-)
AKR/J MGP_AKRJ_G0026369
protein coding gene Chr2:127045462-127109093 (-)
BALB/cJ MGP_BALBcJ_G0026405
protein coding gene Chr2:123805402-123867330 (-)
C3H/HeJ MGP_C3HHeJ_G0026149
protein coding gene Chr2:127532038-127597156 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026851
protein coding gene Chr2:132859184-132923496 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024228
protein coding gene Chr2:118296950-118357195 (-)
CAST/EiJ MGP_CASTEiJ_G0025610
protein coding gene Chr2:127776886-127843807 (-)
CBA/J MGP_CBAJ_G0026129
protein coding gene Chr2:137679729-137751392 (-)
DBA/2J MGP_DBA2J_G0026263
protein coding gene Chr2:122929837-122991631 (-)
FVB/NJ MGP_FVBNJ_G0026227
protein coding gene Chr2:121615170-121682104 (-)
LP/J MGP_LPJ_G0026368
protein coding gene Chr2:128986585-129051817 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026247
protein coding gene Chr2:141805222-141871729 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026906
protein coding gene Chr2:127077600-127142245 (-)
PWK/PhJ MGP_PWKPhJ_G0025346
protein coding gene Chr2:122455496-122534244 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025148
protein coding gene Chr2:126149055-126219412 (-)
WSB/EiJ MGP_WSBEiJ_G0025684
protein coding gene Chr2:127982059-128047751 (-)



Homology
more
  • Human Ortholog
    CEP152, centrosomal protein 152
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CEP152, centrosomal protein 152
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCPH4, MCPH9, SCKL5
  • Links
    NCBI Gene ID: 22995
    neXtProt AC: NX_O94986
    UniProt: O94986

  • Chr Location
    15q21.1; chr15:48662534-48811901 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37159
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CEP152
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human CEP152 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a null allele exhibit reduced numbers of centrosomes and cilia, increased apoptosis, and midgestation lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068394 Ensembl Gene Model | MGI Sequence Detail 62026 C57BL/6J ±  kb
transcript ENSMUST00000089776 Ensembl | MGI Sequence Detail 5768 Not Applicable  
polypeptide ENSMUSP00000087208 Ensembl | MGI Sequence Detail 1736 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:228085 Hein MY, et al., A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances. Cell. 2015 Oct 22;163(3):712-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory