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Gpr107 Gene Detail
Summary
  • Symbol
    Gpr107
  • Name
    G protein-coupled receptor 107
  • Synonyms
    mKIAA1624
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139054
    NCBI Gene: 277463
  • Gene Overview
    MyGene.info: GPR107
Location & Maps
more
  • Sequence Map
    Chr2:31152316-31218775 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66460 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.80 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GPR107, G protein-coupled receptor 107
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPR107, G protein-coupled receptor 107
    Orthology source: HomoloGene
  • Synonyms
    bA138E2.2, GCDRP, LUSTR1
  • Links
    NCBI Gene ID: 57720
    neXtProt AC: NX_Q5VW38

  • Chr Location
    9q34.11; chr9:130053706-130140169 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes embryonic lethality between E11.5 and E12.5, associated with reduced expression of genes implicated in the cubilin-megalin multi-ligand endocytic receptor complex. Homozygous null MEFs show defects in receptor-mediated endocytosis and recycling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011925 VEGA Gene Model | MGI Sequence Detail 66460 C57BL/6J ±  kb
transcript OTTMUST00000028145 VEGA | MGI Sequence Detail 6134 Not Applicable  
polypeptide OTTMUSP00000012741 VEGA | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    548 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008184 protein GPR107
  • InterPro Domains
    IPR009637 Lung seven transmembrane receptor-like
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 5
References
more
  • Summaries
    All 33
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:215242 Zhou GL, et al., Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption. J Cell Sci. 2014 Sep 15;127(Pt 18):3916-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory