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Slc5a12 Gene Detail
Summary
  • Symbol
    Slc5a12
  • Name
    solute carrier family 5 (sodium/glucose cotransporter), member 12
  • Synonyms
    SMCT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138890
    NCBI Gene: 241612
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:110427643-110478124 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 56.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    433 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138890
protein coding gene Chr2:110427643-110479690 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026246
protein coding gene Chr2:112941607-112998045 (+)
A/J MGP_AJ_G0026207
protein coding gene Chr2:108221392-108285532 (+)
AKR/J MGP_AKRJ_G0026187
protein coding gene Chr2:111270093-111326277 (+)
BALB/cJ MGP_BALBcJ_G0026217
protein coding gene Chr2:108524808-108582680 (+)
C3H/HeJ MGP_C3HHeJ_G0025966
protein coding gene Chr2:111554598-111605484 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026668
protein coding gene Chr2:116630239-116687681 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024053
protein coding gene Chr2:103722721-103771806 (+)
CAST/EiJ MGP_CASTEiJ_G0025431
protein coding gene Chr2:112028526-112094064 (+)
CBA/J MGP_CBAJ_G0025944
protein coding gene Chr2:120622509-120692907 (+)
DBA/2J MGP_DBA2J_G0026082
protein coding gene Chr2:107729982-107780400 (+)
FVB/NJ MGP_FVBNJ_G0026045
protein coding gene Chr2:106644654-106698022 (+)
LP/J MGP_LPJ_G0026185
protein coding gene Chr2:113127870-113191375 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026069
protein coding gene Chr2:124821028-124884645 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026721
protein coding gene Chr2:111428588-111488735 (+)
PWK/PhJ MGP_PWKPhJ_G0025166
protein coding gene Chr2:107340612-107392221 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024966
protein coding gene Chr2:110670273-110733467 (+)
WSB/EiJ MGP_WSBEiJ_G0025498
protein coding gene Chr2:112177514-112238190 (+)



Homology
more
  • Human Ortholog
    SLC5A12, solute carrier family 5 member 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC5A12, solute carrier family 5 member 12
  • Synonyms
    SMCT2
  • Links
    NCBI Gene ID: 159963
    neXtProt AC: NX_Q1EHB4
    UniProt: Q1EHB4

  • Chr Location
    11p14.2; chr11:26667020-26723427 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041644 Ensembl Gene Model | MGI Sequence Detail 50482 C57BL/6J ±  kb
transcript ENSMUST00000045972 Ensembl | MGI Sequence Detail 3529 Not Applicable  
polypeptide ENSMUSP00000047340 Ensembl | MGI Sequence Detail 623 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015168 sodium-coupled monocarboxylate transporter 2
  • InterPro Domains
    IPR042700 Sodium-coupled monocarboxylate transporter 2, solute-binding domain
    IPR038377 Sodium/glucose symporter superfamily
    IPR001734 Sodium/solute symporter
Molecular
Reagents
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  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory