Dlgap4 MGI Mouse Gene Detail - MGI:2138865

Symbol

Dlgap4
Name

DLG associated protein 4
Synonyms

DAP4, MGC:37636, mKIAA0964, PSD-95/SAP90 binding protein 4, SAP90/PSD-95-associated protein 4, Sapap4, WBP16

Feature Type

protein coding gene
IDs

MGI:2138865
NCBI Gene: 228836
Gene Overview

MyGene.info: DLGAP4
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr2:156613705-156764363 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.54 cM
Mapping Data

2 experiments

SNPs within 2kb

1626 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138865	protein coding gene	Chr2:156613633-156764363 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0026766	protein coding gene	Chr2:161522348-161683963 (+)
A/J	MGP_AJ_G0026732	protein coding gene	Chr2:155094627-155249477 (+)
AKR/J	MGP_AKRJ_G0026703	protein coding gene	Chr2:159600276-159760905 (+)
BALB/cJ	MGP_BALBcJ_G0026741	protein coding gene	Chr2:155386597-155536938 (+)
C3H/HeJ	MGP_C3HHeJ_G0026484	protein coding gene	Chr2:159939653-160098309 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027190	protein coding gene	Chr2:166236332-166403597 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024560	protein coding gene	Chr2:148558430-148708669 (+)
CAST/EiJ	MGP_CASTEiJ_G0025945	protein coding gene	Chr2:160283500-160445505 (+)
CBA/J	MGP_CBAJ_G0026461	protein coding gene	Chr2:172299240-172474922 (+)
DBA/2J	MGP_DBA2J_G0026598	protein coding gene	Chr2:154265102-154418618 (+)
FVB/NJ	MGP_FVBNJ_G0026565	protein coding gene	Chr2:152633911-152788195 (+)
LP/J	MGP_LPJ_G0026703	protein coding gene	Chr2:161642172-161805619 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026586	protein coding gene	Chr2:176201939-176364644 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027246	protein coding gene	Chr2:159464988-159622218 (+)
PWK/PhJ	MGP_PWKPhJ_G0025679	protein coding gene	Chr2:153765443-153924957 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025482	protein coding gene	Chr2:158505070-158567914 (+)
WSB/EiJ	MGP_WSBEiJ_G0026015	protein coding gene	Chr2:160352701-160516261 (+)

Human Ortholog

DLGAP4, DLG associated protein 4

Vertebrate Orthologs

9

Human Ortholog

DLGAP4, DLG associated protein 4
Orthology source: HomoloGene, HGNC
Synonyms

DAP4, DAP-4, DLP4, SAPAP4, SAPAP-4
Links

HGNC:24476

NCBI Gene ID: 22839

neXtProt AC: NX_Q9Y2H0

UniProt: Q9Y2H0
Chr Location

20q11.23; chr20:36306323-36528637 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8935
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DLGAP4
Gene Tree

Dlgap4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

251
Gene trapped

248
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

153 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

161
Tissues

19
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dlgap4

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Dlgap4 interacts with 319 markers (Mir1b, Mir7-2, Mir7b, ...) View All

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All Sequences

136
RefSeq

41
UniProt

10
CCDS

CCDS16968.1, CCDS38299.1, CCDS38300.1, CCDS71171.1, CCDS71172.1

Ensembl

ENSMUSG00000061689 (Evidence)
NCBI Gene

228836

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061689	Ensembl Gene Model \| MGI Sequence Detail	150659	C57BL/6J	± kb
transcript	ENSMUST00000169464	Ensembl \| MGI Sequence Detail	4851	Not Applicable
polypeptide	ENSMUSP00000126980	Ensembl \| MGI Sequence Detail	992	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006519 disks large-associated protein 4

(term hierarchy)
InterPro Domains

IPR030527 Disks large-associated protein 4

IPR005026 SAPAP family

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All nucleic 11

cDNA 11

Microarray probesets 5

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MGI:2385162

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 11
Earliest

J:71028 Bedford MT, et al., A novel pro-Arg motif recognized by WW domains. J Biol Chem. 2000 Apr 7;275(14):10359-69
Latest

J:228732 Berg JM, et al., JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron. 2015 Dec 16;88(6):1173-91

TSS for Dlgap4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21178	Chr2:156613466-156613491 (+)	-226 bp
Tssr21179	Chr2:156613628-156613639 (+)	-71 bp
Tssr21180	Chr2:156613643-156613661 (+)	-53 bp
Tssr21181	Chr2:156613664-156613706 (+)	-20 bp
Tssr21182	Chr2:156721009-156721030 (+)	107,315 bp
Tssr21183	Chr2:156721037-156721055 (+)	107,341 bp
Tssr21184	Chr2:156721069-156721084 (+)	107,372 bp
Tssr21185	Chr2:156721085-156721094 (+)	107,385 bp
Tssr21186	Chr2:156721274-156721290 (+)	107,577 bp
Tssr21187	Chr2:156721293-156721302 (+)	107,593 bp
Tssr21188	Chr2:156721310-156721335 (+)	107,618 bp
Tssr21189	Chr2:156721340-156721345 (+)	107,638 bp
Tssr21190	Chr2:156721364-156721386 (+)	107,670 bp
Tssr21191	Chr2:156721631-156721646 (+)	107,934 bp
Tssr21192	Chr2:156721663-156721680 (+)	107,967 bp
Tssr21193	Chr2:156721845-156721870 (+)	108,153 bp
Tssr21201	Chr2:156749159-156749205 (+)	135,477 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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