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Ldlrad3 Gene Detail
Summary
  • Symbol
    Ldlrad3
  • Name
    low density lipoprotein receptor class A domain containing 3
  • Synonyms
    Lrad3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138856
    NCBI Gene: 241576
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:101950203-102186385 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3295 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138856
protein coding gene Chr2:101950201-102186460 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026194
protein coding gene Chr2:103833689-104082350 (-)
A/J MGP_AJ_G0026155
protein coding gene Chr2:99556918-99808468 (-)
AKR/J MGP_AKRJ_G0026136
protein coding gene Chr2:102270018-102508789 (-)
BALB/cJ MGP_BALBcJ_G0026164
protein coding gene Chr2:99855351-100091320 (-)
C3H/HeJ MGP_C3HHeJ_G0025915
protein coding gene Chr2:102637144-102877255 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026615
protein coding gene Chr2:107346126-107592803 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024006
protein coding gene Chr2:95263000-95498332 (-)
CAST/EiJ MGP_CASTEiJ_G0025380
protein coding gene Chr2:103053101-103301848 (-)
CBA/J MGP_CBAJ_G0025893
protein coding gene Chr2:111054551-111300718 (-)
DBA/2J MGP_DBA2J_G0026029
protein coding gene Chr2:99143220-99380832 (-)
FVB/NJ MGP_FVBNJ_G0025992
protein coding gene Chr2:98137956-98377374 (-)
LP/J MGP_LPJ_G0026133
protein coding gene Chr2:104003903-104247580 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026018
protein coding gene Chr2:115031084-115277720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026669
protein coding gene Chr2:102479036-102723785 (-)
PWK/PhJ MGP_PWKPhJ_G0025115
protein coding gene Chr2:98616125-98859005 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024916
protein coding gene Chr2:101687214-101932186 (-)
WSB/EiJ MGP_WSBEiJ_G0025447
protein coding gene Chr2:103181703-103423049 (-)



Homology
more
  • Human Ortholog
    LDLRAD3, low density lipoprotein receptor class A domain containing 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LDLRAD3, low density lipoprotein receptor class A domain containing 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LRAD3
  • Links
    NCBI Gene ID: 143458
    neXtProt AC: NX_Q86YD5
    UniProt: Q86YD5

  • Chr Location
    11p13; chr11:35943981-36232136 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    122
  • Chemically induced (other)
    1
  • Gene trapped
    118
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Ldlrad3
  • Incidental Mutations
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048058 Ensembl Gene Model | MGI Sequence Detail 236183 C57BL/6J ±  kb
transcript ENSMUST00000058790 Ensembl | MGI Sequence Detail 3833 Not Applicable  
polypeptide ENSMUSP00000054134 Ensembl | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000032554 low-density lipoprotein receptor class A domain-containing protein 3
  • InterPro Domains
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:269738 Guerreiro I, et al., Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan. Elife. 2016 Aug 1;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory