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Eps8l2
Gene Detail
Symbol

Name
ID
Eps8l2
EPS8-like 2
MGI:2138828
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:141338880-141363020 bp, + strand
From VEGA annotation of GRCm38

  24141 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69358  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 3 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eps8l2

Human
homologs
Human Homolog EPS8L2, EPS8-like 2
NCBI Gene ID 64787
neXtProt AC  NX_Q9H6S3
Human Synonyms  EPS8R2
Human Chr (Location)  11p15.5; chr11:706117-727727 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(44) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display late onset progressive hearing loss and gradual deterioration of cochlear hair cell stereocilliary bundles.
 
Interactions
Eps8l2 interacts with 148 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (317)    Tissues (86)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 298
Northern blot 8
RT-PCR 11
cDNA source data(103)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(105) cDNA(103) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024549 (Evidence)
Ensembl Gene ModelENSMUSG00000025504 (Evidence)
Entrez Gene98845 (Evidence)
UniGene27451
DFCITC1590841, TC1574532
NIA Mouse Gene IndexU008957
Consensus CDS ProjectCCDS22009.1
International Mouse Knockout Project StatusEps8l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024549 VEGA Gene Model | MGI Sequence Detail 24141 C57BL/6J ±  kb
transcript OTTMUST00000060290 VEGA | MGI Sequence Detail 3191 Not Applicable 
polypeptide OTTMUSP00000029403 VEGA | MGI Sequence Detail 729 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR013625 Tensin phosphotyrosine-binding domain
Protein Ontology PR:000007149 epidermal growth factor receptor kinase substrate 8-like protein 2
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:200669 Furness DN, et al., Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13898-903
All references(32)
Other
accession IDs
MGI:2142251

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory