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Fcrla
Gene Detail
Symbol

Name
ID
Fcrla
Fc receptor-like A
MGI:2138647
Synonyms
FCRL1, Fcrx, FREB, Freb1, mFcrX, mFREB
Feature Type
protein coding gene
Genetic Map
Chromosome 1
77.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:170917576-170927583 bp, - strand
From VEGA annotation of GRCm38

  10008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13106  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: FCRLA
Gene Tree: Fcrla

Human
homologs
FCRLA, Fc receptor-like A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84824
neXtProt AC: NX_Q7L513

Human Synonyms: FCRL, FCRL1, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRLM1, FCRLX, FCRX, FREB

Human Chr (Location): 1q23.3; chr1:161706972-161714352 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit largely normal T-dependent and T-independent antibody responses with an increase in IgG1 after secondary challenge with sheep red blood cells.
 
Interactions
Fcrla interacts with 90 markers (Mir10a, Mir10b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process cell differentiation
Component cytoplasm, extracellular region
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000029894 (Evidence)
Ensembl Gene Model ENSMUSG00000038421 (Evidence)
Entrez Gene 98752 (Evidence)
UniGene 1850
DFCI TC1583672, TC1643623, TC1685212
DoTS DT.97359399, DT.94295829
NIA Mouse Gene Index U022040
Consensus CDS Project CCDS48439.1, CCDS48440.1
International Mouse Phenotyping Consortium Status Fcrla
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029894 VEGA Gene Model | MGI Sequence Detail 10008 C57BL/6J ±  kb
transcript OTTMUST00000074170 VEGA | MGI Sequence Detail 1679 Not Applicable 
polypeptide OTTMUSP00000038502 VEGA | MGI Sequence Detail 353 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000007445 Fc receptor-like A
References
(Earliest) J:73936 Mechetina LV, et al., FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features. Eur J Immunol. 2002 Jan;32(1):87-96
(Latest) J:181376 Reshetnikova ES, et al., Differential expression of FCRLA in naive and activated mouse B cells. Cell Immunol. 2012;272(2):182-92
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory