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Fcrla Gene Detail
Summary
  • Symbol
    Fcrla
  • Name
    Fc receptor-like A
  • Synonyms
    FCRL1, Fcrx, FREB, Freb1, mFcrX, mFREB
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138647
    NCBI Gene: 98752
  • Gene Overview
    MyGene.info: FCRLA
Location & Maps
more
  • Sequence Map
    Chr1:170917576-170927583 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10008 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 77.65 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FCRLA, Fc receptor like A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FCRLA, Fc receptor like A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FCRL, FCRL1, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRLM1, FCRLX, FCRX, FREB
  • Links
    NCBI Gene ID: 84824
    neXtProt AC: NX_Q7L513

  • Chr Location
    1q23.3; chr1:161706972-161714352 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Fcrla
  • Incidental Mutations
Mice homozygous for a targeted allele exhibit largely normal T-dependent and T-independent antibody responses with an increase in IgG1 after secondary challenge with sheep red blood cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029894 VEGA Gene Model | MGI Sequence Detail 10008 C57BL/6J ±  kb
transcript OTTMUST00000074170 VEGA | MGI Sequence Detail 1679 Not Applicable  
polypeptide OTTMUSP00000038502 VEGA | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    162 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 6
References
more
  • Summaries
    All 31
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:73936 Mechetina LV, et al., FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features. Eur J Immunol. 2002 Jan;32(1):87-96
  • Latest
    J:181376 Reshetnikova ES, et al., Differential expression of FCRLA in naive and activated mouse B cells. Cell Immunol. 2012;272(2):182-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory