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Gigyf2 Gene Detail
Summary
  • Symbol
    Gigyf2
  • Name
    GRB10 interacting GYF protein 2
  • Synonyms
    2610016F01Rik, A830080H02Rik, mKIAA0642, Tnrc15
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138584
    NCBI Gene: 227331
  • Gene Overview
    MyGene.info: GIGYF2
Location & Maps
more
  • Sequence Map
    Chr1:87326998-87450796 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      123799 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.23 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GIGYF2, GRB10 interacting GYF protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GIGYF2, GRB10 interacting GYF protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GYF2, PARK11, PERQ2, PERQ3, TNRC15
  • Links
    NCBI Gene ID: 26058
    neXtProt AC: NX_Q6Y7W6

  • Chr Location
    2q37.1; chr2:232697305-232860577 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GIGYF2 associations

Human Disease Mouse Models
       Parkinson Disease 11, Autosomal Dominant, Susceptibility To; PARK11   OMIM: 607688
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    110
  • Chemically induced (other)
    1
  • Gene trapped
    107
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Gigyf2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit neonatal and postnatal lethality. Mice heterozygous for a knock-out allele exhibit impaired motor coordination with motor neuron degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037064 VEGA Gene Model | MGI Sequence Detail 123799 C57BL/6J ±  kb
transcript OTTMUST00000095344 VEGA | MGI Sequence Detail 3876 Not Applicable  
polypeptide OTTMUSP00000053206 VEGA | MGI Sequence Detail 1291 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    409 from dbSNP Build 142
Protein
Information
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  • UniProt
    15 Sequences
  • Protein Ontology
    PR:000007977 PERQ amino acid-rich with GYF domain-containing protein 2
  • InterPro Domains
    IPR003169 GYF domain
Molecular
Reagents
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  • All nucleic 142
    cDNA 141
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1916462, MGI:2146509, MGI:3039589
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:188802 Morita M, et al., A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol. 2012 Sep;32(17):3585-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory