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Gigyf2
Gene Detail
Symbol

Name
ID
Gigyf2
GRB10 interacting GYF protein 2
MGI:2138584
Synonyms
2610016F01Rik, A830080H02Rik, mKIAA0642, Tnrc15
Feature Type
protein coding gene
Genetic Map
Chromosome 1
44.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:87326998-87450796 bp, + strand
From VEGA annotation of GRCm38

  123799 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41048  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GIGYF2
Gene Tree: Gigyf2

Human
homologs
GIGYF2, GRB10 interacting GYF protein 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 26058
neXtProt AC: NX_Q6Y7W6

Human Synonyms: GYF2, PARK11, PERQ2, PERQ3, TNRC15

Human Chr (Location): 2q37.1; chr2:232697305-232860577 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GIGYF2

Mutations,
alleles, and
phenotypes
All mutations/alleles(108) : Gene trapped(107) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit neonatal and postnatal lethality. Mice heterozygous for a knock-out allele exhibit impaired motor coordination with motor neuron degeneration.
 
Interactions
Gigyf2 interacts with 325 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process adult locomotory behavior, cellular protein metabolic process, ...
Component cytoplasm, membrane
Function poly(A) RNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (30)    Tissues (18)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 16
Northern blot 11
Western blot 3
cDNA source data(140)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gigyf2 ; ZFIN gigfy2    NEW 
Molecular
reagents
All nucleic(142) cDNA(141) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000037064 (Evidence)
Ensembl Gene Model ENSMUSG00000048000 (Evidence)
Entrez Gene 227331 (Evidence)
UniGene 23065
DFCI TC1597055, TC1716398, TC1601361, TC1581525, TC1594939, TC1578083, TC1607012
DoTS DT.101398580, DT.102543053, DT.101324032, DT.101133038, DT.101398579, DT.97388615, DT.97409938, DT.91370790, DT.60108398
NIA Mouse Gene Index U000557
Consensus CDS Project CCDS15133.1, CCDS56636.1
International Mouse Phenotyping Consortium Status Gigyf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037064 VEGA Gene Model | MGI Sequence Detail 123799 C57BL/6J ±  kb
transcript OTTMUST00000095340 VEGA | MGI Sequence Detail 5724 Not Applicable 
polypeptide OTTMUSP00000053203 VEGA | MGI Sequence Detail 1291 Not Applicable 

For the selected sequences
All sequences(151) RefSeq(19) UniProt(15)
Polymorphisms
SNPs within 2kb(410 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003169 GYF
Protein Ontology PR:000007977 PERQ amino acid-rich with GYF domain-containing protein 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188802 Morita M, et al., A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol. 2012 Sep;32(17):3585-93
All references(40)
Other
accession IDs
MGI:1916462, MGI:2146509, MGI:3039589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory