Gigyf2
Gene Detail

Symbol Name ID

Gigyf2 GRB10 interacting GYF protein 2 MGI:2138584

Synonyms

2610016F01Rik, A830080H02Rik, mKIAA0642, Tnrc15

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:87326998-87450796 bp, + strand From VEGA annotation of GRCm38   123799 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41048  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gigyf2

Human homologs

Human Homolog		GIGYF2, GRB10 interacting GYF protein 2
NCBI Gene ID		26058
neXtProt AC		NX_Q6Y7W6
Human Synonyms		GYF2, PARK11, PERQ2, PERQ3, TNRC15
Human Chr (Location)		2q37.1; chr2:233562015-233725287 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GIGYF2

Alleles and phenotypes

All alleles(108) : Targeted(1) Gene trapped(107)
 

Mice homozygous for a knock-out allele exhibit neonatal and postnatal lethality. Mice heterozygous for a knock-out allele exhibit impaired motor coordination with motor neuron degeneration.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	adult locomotory behavior, cellular protein metabolic process, ...
Component	cellular_component
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (30)    Tissues (18)    Images (1)
Theiler Stages: 19, 22, 25, 28

Assay Type	Results
In situ reporter (knock in)	16
Northern blot	11
Western blot	3

cDNA source data(138)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(140) cDNA(139) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000037064 (Evidence)
Ensembl Gene Model	ENSMUSG00000048000 (Evidence)
Entrez Gene	227331 (Evidence)
UniGene	23065
DFCI	TC1578083, TC1581525, TC1594939, TC1597055, TC1601361, TC1607012, TC1716398
DoTS	DT.101133038, DT.101324032, DT.101398579, DT.101398580, DT.102543053, DT.60108398, DT.91370790, DT.97388615, DT.97409938
NIA Mouse Gene Index	U000557
Consensus CDS Project	CCDS15133.1, CCDS56636.1
International Mouse Knockout Project Status	Gigyf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037064	VEGA Gene Model | MGI Sequence Detail	123799	C57BL/6J
transcript	OTTMUST00000095340	VEGA | MGI Sequence Detail	5724	Not Applicable
polypeptide	OTTMUSP00000053203	VEGA | MGI Sequence Detail	1291	Not Applicable

All sequences(134) RefSeq(4) UniProt(15)

Polymorphisms

SNPs(288 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003169	GYF
Protein Ontology	PR:000007977	PERQ amino acid-rich with GYF domain-containing protein 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188802 Morita M, et al., A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol. 2012 Sep;32(17):3585-93
All references(41)

Other accession IDs

MGI:1916462, MGI:2146509, MGI:3039589