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Gigyf2
Gene Detail
 Symbol
Name
ID
Gigyf2
GRB10 interacting GYF protein 2
MGI:2138584
Synonyms 2610016F01Rik, A830080H02Rik, mKIAA0642, Tnrc15
Feature Type protein coding gene
Genetic Map
Chromosome 1
44.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:87326998-87450796 bp, + strand
From VEGA annotation of GRCm38

  123799 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41048  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gigyf2

Human
homologs
Human Homolog GIGYF2, GRB10 interacting GYF protein 2
NCBI Gene ID 26058
neXtProt AC  NX_Q6Y7W6
Human Synonyms  GYF2, PARK11, PERQ2, PERQ3, TNRC15
Human Chr (Location)  2q37.1; chr2:232697305-232860577 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GIGYF2
Mutations,
alleles, and
phenotypes
All mutations/alleles(108) : Gene trapped(107) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal and postnatal lethality. Mice heterozygous for a knock-out allele exhibit impaired motor coordination with motor neuron degeneration.
 
Interactions
Gigyf2 interacts with 326 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process adult locomotory behavior, cellular protein metabolic process, ...
Component membrane
Function poly(A) RNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (30)    Tissues (18)    Images (1)
Theiler Stages: 19, 22, 25, 28
Assay TypeResults
In situ reporter (knock in) 16
Northern blot 11
Western blot 3
cDNA source data(140)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(142) cDNA(141) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037064 (Evidence)
Ensembl Gene ModelENSMUSG00000048000 (Evidence)
Entrez Gene227331 (Evidence)
UniGene23065
DFCITC1578083, TC1581525, TC1594939, TC1597055, TC1601361, TC1607012, TC1716398
DoTSDT.101133038, DT.101324032, DT.101398579, DT.101398580, DT.102543053, DT.60108398, DT.91370790, DT.97388615, DT.97409938
NIA Mouse Gene IndexU000557
Consensus CDS ProjectCCDS15133.1, CCDS56636.1
International Mouse Knockout Project StatusGigyf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037064 VEGA Gene Model | MGI Sequence Detail 123799 C57BL/6J ±  kb
transcript OTTMUST00000095340 VEGA | MGI Sequence Detail 5724 Not Applicable 
polypeptide OTTMUSP00000053203 VEGA | MGI Sequence Detail 1291 Not Applicable 

For the selected sequences
All sequences(150) RefSeq(19) UniProt(15)
Polymorphisms SNPs within 2kb(410 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003169 GYF
Protein Ontology PR:000007977 PERQ amino acid-rich with GYF domain-containing protein 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188802 Morita M, et al., A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol. 2012 Sep;32(17):3585-93
All references(41)
Other
accession IDs
MGI:1916462, MGI:2146509, MGI:3039589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory