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Sulf1
Gene Detail
Symbol

Name
ID
Sulf1
sulfatase 1
MGI:2138563
Feature Type
protein coding gene
Genetic Map
Chromosome 1
3.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:12692277-12861192 bp, + strand
From VEGA annotation of GRCm38

  168916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49408  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SULF1
Protein SuperFamily: extracellular sulfatase
Gene Tree: Sulf1

Human
homologs
SULF1, sulfatase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23213
neXtProt AC: NX_Q8IWU6

Human Synonyms: HSULF-1, SULF-1

Human Chr (Location): 8q13.2; chr8:69466624-69660912 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(108) : Gene trapped(101) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele display a slight increase in mortality early in life.
 
Phenotype Images(3)
Interactions
Sulf1 interacts with 271 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process apoptotic process, bone development, ...
Component cell surface, endoplasmic reticulum, ...
Function alkyl sulfatase activity, arylsulfatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (167)    Tissues (133)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 152
In situ reporter (knock in) 1
RT-PCR 14
cDNA source data(160)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sulf1 ; ZFIN sulf1    NEW 
Molecular
reagents
All nucleic(167) cDNA(162) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000047995 (Evidence)
Ensembl Gene Model ENSMUSG00000016918 (Evidence)
Entrez Gene 240725 (Evidence)
UniGene 45563
DFCI TC1582005, TC1576991, TC1602890, TC1615121, TC1624413, TC1620145
DoTS DT.94294891, DT.94245132, DT.97375184, DT.91332845, DT.40149776, DT.101738696, DT.101738698, DT.101710302
NIA Mouse Gene Index U000046
EC 3.1.6.-
Consensus CDS Project CCDS14820.1
International Mouse Phenotyping Consortium Status Sulf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047995 VEGA Gene Model | MGI Sequence Detail 168916 C57BL/6J ±  kb
transcript OTTMUST00000123376 VEGA | MGI Sequence Detail 5598 Not Applicable 
polypeptide OTTMUSP00000067394 VEGA | MGI Sequence Detail 870 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(1106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR014615 Extracellular sulfatase
InterPro IPR024609 Extracellular sulfatase, C-terminal
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000015816 extracellular sulfatase Sulf-1
References
(Earliest) J:80928 Morimoto-Tomita M, et al., Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans. J Biol Chem. 2002 Dec 20;277(51):49175-85
(Latest) J:218261 Freeman SD, et al., Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development. Dev Dyn. 2015 Feb;244(2):168-80
All references(63)
Other
accession IDs
MGI:2138273

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory