Sulf1 MGI Mouse Gene Detail - MGI:2138563

Symbol

Sulf1
Name

sulfatase 1

Feature Type

protein coding gene
IDs

MGI:2138563
NCBI Gene: 240725
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:12762501-12931416 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 3.35 cM
Mapping Data

1 experiment

SNPs within 2kb

4904 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138563	protein coding gene	Chr1:12762421-12946090 (+)
129S1/SvImJ	ENSMUSG00200018370	protein coding gene	Chr1:10178859-10253775 (+)
A/J	ENSMUSG00195002901	protein coding gene	Chr1:10006334-10081118 (+)
AKR/J	ENSMUSG00220003378	protein coding gene	Chr1:10076859-10151636 (+)
BALB/cJ	ENSMUSG00180008797	protein coding gene	Chr1:10072686-10147471 (+)
C3H/HeJ	ENSMUSG00175000177	protein coding gene	Chr1:9994475-10069641 (+)
C57BL/6NJ	ENSMUSG00215003875	protein coding gene	Chr1:10051624-10126401 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013951	protein coding gene	Chr1:8660993-8826967 (+)
CAST/EiJ	ENSTCUG00005021388	protein coding gene	Chr1:10452489-10527025 (+)
CBA/J	ENSMUSG00210001538	protein coding gene	Chr1:9864990-9940128 (+)
DBA/2J	ENSMUSG00185003873	protein coding gene	Chr1:10938117-11012833 (+)
FVB/NJ	ENSMUSG00205013520	protein coding gene	Chr1:10155184-10229903 (+)
JF1/MsJ	ENSUMUG00000017148	protein coding gene	Chr1:10240120-10313900 (+)
LP/J	ENSMUSG00230017584	protein coding gene	Chr1:10908258-10983170 (+)
NOD/ShiLtJ	ENSMUSG00190001067	protein coding gene	Chr1:9979916-10054700 (+)
NZO/HlLtJ	ENSMUSG00225005250	protein coding gene	Chr1:14306687-14381455 (+)
PWK/PhJ	ENSLUMG00010002236	protein coding gene	Chr1:9829564-9904380 (+)
SPRET/EiJ	ENSMSPG00010025070	protein coding gene	Chr1:10522944-10595561 (+)
WSB/EiJ	ENSIUOG00005011050	protein coding gene	Chr1:10010448-10085232 (+)

Human Ortholog

SULF1, sulfatase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SULF1, sulfatase 1
Synonyms

SULF-1
Links

HGNC:20391

NCBI Gene ID: 23213

UniProt: Q8IWU6
Chr Location

8q13.2-q13.3; chr8:69466624-69660935 (+) GRCh38

MGI Vertebrate Homology

Sulf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SULF1
Protein SuperFamily

Sulf1
Gene Tree

Sulf1

less

Phenotype Summary

13 phenotypes from 6 alleles in 6 genetic backgrounds
52 phenotypes from multigenic genotypes
3 images
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

89
Endonuclease-mediated

3
Gene trapped

77
Targeted

9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

113 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display a slight increase in mortality early in life.

less

All GO Annotations

97
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

955
Tissues

239
cDNA Data

166
Literature Summary

32

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sulf1

ZFIN sulf1

less

All Sequences

79
RefSeq

20
UniProt

5
CCDS

CCDS14820.1

Ensembl

ENSMUSG00000016918 (Evidence)
NCBI Gene

240725

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016918	Ensembl Gene Model \| MGI Sequence Detail	168916	C57BL/6J	± kb
transcript	ENSMUST00000177608	Ensembl \| MGI Sequence Detail	5598	Not Applicable
polypeptide	ENSMUSP00000137523	Ensembl \| MGI Sequence Detail	870	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000015816 extracellular sulfatase Sulf-1

(term hierarchy)
EC

3.1.6.1, 3.1.6.14
InterPro Domains

IPR017850 Alkaline-phosphatase-like, core domain superfamily

IPR014615 Extracellular sulfatase

IPR024609 Extracellular sulfatase, C-terminal

IPR024607 Sulfatase, conserved site

IPR000917 Sulfatase domain
GlyGen

Q8K007 10 sites, 2 N-linked glycans (4 sites)

less

All nucleic 184

cDNA 168

Primer pair 12

Other 4

Antibodies 1

Microarray probesets 3

less

MGI:2138273

Summaries

All 105

Developmental Gene Expression 32

Gene Ontology 18

Phenotypes 44
Earliest

J:80928 Morimoto-Tomita M, et al., Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans. J Biol Chem. 2002 Dec 20;277(51):49175-85
Latest

J:391329 Duan CH, et al., Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming. Nat Commun. 2026 Jul 1;17(1)

TSS for Sulf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5948	Chr1:12762582-12762589 (+)	85 bp
Tssr5949	Chr1:12762629-12762643 (+)	135 bp
Tssr5950	Chr1:12762657-12762709 (+)	182 bp
Tssr5951	Chr1:12762713-12762763 (+)	237 bp
Tssr5952	Chr1:12762766-12762778 (+)	271 bp
Tssr5953	Chr1:12762793-12762809 (+)	300 bp
Tssr5954	Chr1:12788720-12788737 (+)	26,228 bp
Tssr5955	Chr1:12788897-12788977 (+)	26,436 bp
Tssr5956	Chr1:12795597-12795598 (+)	33,097 bp
Tssr5957	Chr1:12814999-12815006 (+)	52,502 bp
Tssr5958	Chr1:12842358-12842361 (+)	79,859 bp
Tssr5959	Chr1:12878072-12878111 (+)	115,591 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29