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Sulf1 Gene Detail
Summary
  • Symbol
    Sulf1
  • Name
    sulfatase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138563
    NCBI Gene: 240725
  • Gene Overview
    MyGene.info: SULF1
Location & Maps
more
  • Sequence Map
    Chr1:12692277-12861192 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      168916 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SULF1, sulfatase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SULF1, sulfatase 1
    Orthology source: HomoloGene
  • Synonyms
    SULF-1
  • Links
    NCBI Gene ID: 23213
    neXtProt AC: NX_Q8IWU6

  • Chr Location
    8q13.2; chr8:69466624-69660912 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 5 alleles in 5 genetic backgrounds
    50 phenotypes from multigenic genotypes
    3 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display a slight increase in mortality early in life.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047995 VEGA Gene Model | MGI Sequence Detail 168916 C57BL/6J ±  kb
transcript OTTMUST00000123376 VEGA | MGI Sequence Detail 5598 Not Applicable  
polypeptide OTTMUSP00000067394 VEGA | MGI Sequence Detail 870 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1100 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 167
    cDNA 162
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2138273
References
more
  • Summaries
    All 61
    Developmental Gene Expression 20
    Gene Ontology 13
    Phenotypes 21
  • Earliest
    J:80928 Morimoto-Tomita M, et al., Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans. J Biol Chem. 2002 Dec 20;277(51):49175-85
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory