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Sulf1
Gene Detail
 Symbol
Name
ID
Sulf1
sulfatase 1
MGI:2138563
Feature Type protein coding gene
Genetic Map
Chromosome 1
3.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:12692277-12861192 bp, + strand
From VEGA annotation of GRCm38

  168916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49408  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: extracellular sulfatase
Gene Tree: Sulf1

Human
homologs
Human Homolog SULF1, sulfatase 1
NCBI Gene ID 23213
neXtProt AC  NX_Q8IWU6
Human Synonyms  HSULF-1, SULF-1
Human Chr (Location)  8q13.2; chr8:69466624-69660912 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(108) : Gene trapped(101) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display a slight increase in mortality early in life.
 
Phenotype Images(3)
Interactions
Sulf1 interacts with 272 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process apoptotic process, bone development, ...
Component cell surface, endoplasmic reticulum, ...
Function alkyl sulfatase activity, arylsulfatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (149)    Tissues (121)    Images (46)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 134
In situ reporter (knock in) 1
RT-PCR 14
cDNA source data(160)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(165) cDNA(161) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000047995 (Evidence)
Ensembl Gene ModelENSMUSG00000016918 (Evidence)
Entrez Gene240725 (Evidence)
UniGene45563
DFCITC1576991, TC1582005, TC1602890, TC1615121, TC1620145, TC1624413
DoTSDT.101710302, DT.101738696, DT.101738698, DT.40149776, DT.91332845, DT.94245132, DT.94294891, DT.97375184
NIA Mouse Gene IndexU000046
EC3.1.6.-
Consensus CDS ProjectCCDS14820.1
International Mouse Knockout Project StatusSulf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047995 VEGA Gene Model | MGI Sequence Detail 168916 C57BL/6J ±  kb
transcript OTTMUST00000123376 VEGA | MGI Sequence Detail 5598 Not Applicable 
polypeptide OTTMUSP00000067394 VEGA | MGI Sequence Detail 870 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(19) UniProt(1)
Polymorphisms SNPs within 2kb(1106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR014615 Extracellular sulfatase
InterPro IPR024609 Extracellular sulfatase, C-terminal
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000015816 extracellular sulfatase Sulf-1
References (Earliest) J:80928 Morimoto-Tomita M, et al., Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans. J Biol Chem. 2002 Dec 20;277(51):49175-85
(Latest) J:205898 Maltseva I, et al., The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One. 2013;8(8):e69642
All references(63)
Other
accession IDs
MGI:2138273

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory