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Mael
Gene Detail
Symbol

Name
ID
Mael
maelstrom homolog (Drosophila)
MGI:2138453
Synonyms
4933405K18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
73.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:166201385-166238744 bp, - strand
From VEGA annotation of GRCm38

  37360 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13143  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Mael

Human
homologs
Human Homolog MAEL, maelstrom spermatogenic transposon silencer
NCBI Gene ID 84944
neXtProt AC  NX_Q96JY0
Human Synonyms  CT128, SPATA35
Human Chr (Location)  1q24.1; chr1:166975582-167022214 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a null allele are infertile and display small testes, a complete block of spermatogenesis due to apoptosis during meiotic prophase I, defects in homologous chromosome synapsis, DNA damage, reduced DNA methylation, and derepression of L1 retrotransposons in the adult testis.
 
Interactions
Mael interacts with 47 markers (Mir10a, Mir140, Mir142, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell differentiation, cell morphogenesis, ...
Component autosome, chromatin, ...
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (11)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 8
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(25) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026876 (Evidence)
Ensembl Gene ModelENSMUSG00000040629 (Evidence)
Entrez Gene98558 (Evidence)
UniGene26189
DFCITC1582053
DoTSDT.40172938
NIA Mouse Gene IndexU022003
Consensus CDS ProjectCCDS15448.1
International Mouse Knockout Project StatusMael
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026876 VEGA Gene Model | MGI Sequence Detail 37360 C57BL/6J ±  kb
transcript OTTMUST00000066473 VEGA | MGI Sequence Detail 1546 Not Applicable 
polypeptide OTTMUSP00000033315 VEGA | MGI Sequence Detail 434 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR024970 Maelstrom domain
Protein Ontology PR:000010044 protein maelstrom
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory