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Mael
Gene Detail
Symbol

Name
ID
Mael
maelstrom homolog (Drosophila)
MGI:2138453
Synonyms
4933405K18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
73.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:166201201-166238747 bp, - strand
From VEGA annotation of GRCm38

  37547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13143  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: MAEL
Gene Tree: Mael

Human
homologs
MAEL, maelstrom spermatogenic transposon silencer
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 84944
neXtProt AC: NX_Q96JY0

Human Synonyms: CT128, SPATA35

Human Chr (Location): 1q24.1; chr1:166975582-167022214 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a null allele are infertile and display small testes, a complete block of spermatogenesis due to apoptosis during meiotic prophase I, defects in homologous chromosome synapsis, DNA damage, reduced DNA methylation, and derepression of L1 retrotransposons in the adult testis.
 
Interactions
Mael interacts with 47 markers (Mir10a, Mir140, Mir142, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell differentiation, cell morphogenesis, ...
Component autosome, chromatin, ...
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (11)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 8
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mael    NEW 
Molecular
reagents
All nucleic(26) cDNA(25) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026876 (Evidence)
Ensembl Gene Model ENSMUSG00000040629 (Evidence)
Entrez Gene 98558 (Evidence)
UniGene 26189
DFCI TC1582053
DoTS DT.40172938
NIA Mouse Gene Index U022003
Consensus CDS Project CCDS15448.1
International Mouse Phenotyping Consortium Status Mael
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026876 VEGA Gene Model | MGI Sequence Detail 37547 C57BL/6J ±  kb
transcript OTTMUST00000066473 VEGA | MGI Sequence Detail 1546 Not Applicable 
polypeptide OTTMUSP00000033315 VEGA | MGI Sequence Detail 434 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR024970 Maelstrom domain
Protein Ontology PR:000010044 protein maelstrom
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:214842 Castaneda J, et al., Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice. EMBO J. 2014 Sep 17;33(18):1999-2019
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory