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Mael Gene Detail
Summary
  • Symbol
    Mael
  • Name
    maelstrom spermatogenic transposon silencer
  • Synonyms
    4933405K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138453
    NCBI Gene: 98558
Location & Maps
more
  • Sequence Map
    Chr1:166201201-166238747 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37547 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 73.56 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAEL, maelstrom spermatogenic transposon silencer
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAEL, maelstrom spermatogenic transposon silencer
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CT128, SPATA35
  • Links
    NCBI Gene ID: 84944
    neXtProt AC: NX_Q96JY0

  • Chr Location
    1q24.1; chr1:166975582-167022214 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 13143
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: MAEL
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Mael
  • Incidental Mutations
Male mice homozygous for a null allele are infertile and display small testes, a complete block of spermatogenesis due to apoptosis during meiotic prophase I, defects in homologous chromosome synapsis, DNA damage, reduced DNA methylation, and derepression of L1 retrotransposons in the adult testis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026876 VEGA Gene Model | MGI Sequence Detail 37547 C57BL/6J ±  kb
transcript OTTMUST00000066473 VEGA | MGI Sequence Detail 1546 Not Applicable  
polypeptide OTTMUSP00000033315 VEGA | MGI Sequence Detail 434 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    235 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:229620 Genzor P, et al., A unique HMG-box domain of mouse Maelstrom binds structured RNA but not double stranded DNA. PLoS One. 2015;10(3):e0120268

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory