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Atg9a Gene Detail
Summary
  • Symbol
    Atg9a
  • Name
    autophagy related 9A
  • Synonyms
    Apg9l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138446
    NCBI Gene: 245860
  • Gene Overview
    MyGene.info: ATG9A
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75180861-75192010 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138446
protein coding gene Chr1:75180860-75192196 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016175
protein coding gene Chr1:75743098-75755590 (-)
A/J MGP_AJ_G0016158
protein coding gene Chr1:73102641-73114366 (-)
AKR/J MGP_AKRJ_G0016115
protein coding gene Chr1:75131627-75142968 (-)
BALB/cJ MGP_BALBcJ_G0016113
protein coding gene Chr1:73164660-73175995 (-)
C3H/HeJ MGP_C3HHeJ_G0015944
protein coding gene Chr1:75462221-75474363 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016566
protein coding gene Chr1:78693608-78704944 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014287
protein coding gene Chr1:68663596-68675074 (-)
CAST/EiJ MGP_CASTEiJ_G0015528
protein coding gene Chr1:74800516-74811823 (-)
CBA/J MGP_CBAJ_G0015917
protein coding gene Chr1:81251818-81263148 (-)
DBA/2J MGP_DBA2J_G0016018
protein coding gene Chr1:72421550-72432655 (-)
FVB/NJ MGP_FVBNJ_G0016021
protein coding gene Chr1:71619825-71631172 (-)
LP/J MGP_LPJ_G0016090
protein coding gene Chr1:76867018-76878354 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016041
protein coding gene Chr1:84610047-84622632 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016613
protein coding gene Chr1:75201455-75212799 (-)
PWK/PhJ MGP_PWKPhJ_G0015315
protein coding gene Chr1:71891202-71902559 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015093
protein coding gene Chr1:74561895-74573234 (-)
WSB/EiJ MGP_WSBEiJ_G0015590
protein coding gene Chr1:75012710-75025226 (-)



Homology
more
  • Human Ortholog
    ATG9A, autophagy related 9A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATG9A, autophagy related 9A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APG9L1, mATG9, MGD3208
  • Links
    NCBI Gene ID: 79065
    neXtProt AC: NX_Q7Z3C6
    UniProt: Q7Z3C6

  • Chr Location
    2q35; chr2:219219380-219229688 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 34495
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ATG9A
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation all die within 1 day of birth and display impaired autophagy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 245860 NCBI Gene Model | MGI Sequence Detail 11150 C57BL/6J ±  kb
transcript NM_001288613 RefSeq | MGI Sequence Detail 4104 C57BL/6  
polypeptide Q68FE2 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • InterPro Domains
    IPR007241 Autophagy-related protein 9
Molecular
Reagents
less
  • All nucleic 44
    Genomic 1
    cDNA 43

    Microarray probesets 3
References
more
  • Summaries
    All 58
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 12
    Phenotypes 23
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:261975 De Pace R, et al., Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome. PLoS Genet. 2018 Apr;14(4):e1007363

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory