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Susd4 Gene Detail
Summary
  • Symbol
    Susd4
  • Name
    sushi domain containing 4
  • Synonyms
    E430021N18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138351
    NCBI Gene: 96935
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:182591609-182724161 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 85.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3859 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138351
 protein coding gene Chr1:182591425-182724161 (+)
129S1/SvImJ ENSMUSG00200022142
 protein coding gene Chr1:180358882-180491602 (+)
A/J ENSMUSG00195039096
 protein coding gene Chr1:179945424-180078176 (+)
AKR/J ENSMUSG00220020535
 protein coding gene Chr1:179183056-179322734 (+)
BALB/cJ ENSMUSG00180035169
 protein coding gene Chr1:180010221-180142961 (+)
C3H/HeJ ENSMUSG00175037715
 protein coding gene Chr1:180185896-180318627 (+)
C57BL/6NJ ENSMUSG00215025101
 protein coding gene Chr1:179405236-179538001 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015005
 protein coding gene Chr1:172766875-172895637 (+)
CAST/EiJ ENSTCUG00005040241
 protein coding gene Chr1:177927718-178059105 (+)
CBA/J ENSMUSG00210019000
 protein coding gene Chr1:179829265-179961973 (+)
DBA/2J ENSMUSG00185034353
 protein coding gene Chr1:184448670-184581395 (+)
FVB/NJ ENSMUSG00205024847
 protein coding gene Chr1:178873744-179013423 (+)
JF1/MsJ ENSUMUG00000005114
 protein coding gene Chr1:183463952-183596033 (+)
LP/J ENSMUSG00230021979
 protein coding gene Chr1:184018066-184150784 (+)
NOD/ShiLtJ ENSMUSG00190028683
 protein coding gene Chr1:179861858-179994565 (+)
NZO/HlLtJ ENSMUSG00225010418
 protein coding gene Chr1:187763915-187897930 (+)
PWK/PhJ ENSLUMG00010015767
 protein coding gene Chr1:178697607-178837271 (+)
SPRET/EiJ ENSMSPG00010028462
 protein coding gene Chr1:182185481-182320904 (+)
WSB/EiJ ENSIUOG00005010970
 protein coding gene Chr1:179051618-179184333 (+)



Homology
more
  • Human Ortholog
    SUSD4, sushi domain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUSD4, sushi domain containing 4
  • Synonyms
    PRO222
  • Links
    NCBI Gene ID: 55061
    UniProt: Q5VX71

  • Chr Location
    1q41; chr1:223220819-223365279 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal hippocampal and cerebellar neuronal morphologies, anxiety-like behaviors, defects in motor performance, and increased protein levels of the complement component C1q in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    3
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 96935 NCBI Gene Model | MGI Sequence Detail 132553 C57BL/6J ±  kb
    transcript NM_001356464 RefSeq | MGI Sequence Detail 3059 C57BL/6  
    polypeptide Q8BH32 UniProt | EBI | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138725
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:317347 Gonzalez-Calvo I, et al., Sushi domain-containing protein 4 controls synaptic plasticity and motor learning. Elife. 2021 Mar 4;10:e65712
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory