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Dgkd
Gene Detail
Symbol

Name
ID
Dgkd
diacylglycerol kinase, delta
MGI:2138334
Synonyms
dgkd-2, DGKdelta
Feature Type
protein coding gene
Genetic Map
Chromosome 1
44.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:87853287-87945180 bp, + strand
From VEGA annotation of GRCm38

  91894 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100054  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Dgkd

Human
homologs
Human Homolog DGKD, diacylglycerol kinase, delta 130kDa
NCBI Gene ID 8527
neXtProt AC  NX_Q16760
Human Synonyms  dgkd-2, DGKdelta
Human Chr (Location)  2q37.1; chr2:233354503-233472098 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(5) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are born with open eyelids and reduced body size, develop respiratory distress and die within 24 hrs of birth. Half of mice homozygous for a hypomorphic gene trap allele exhibit abnormal epileptic discharges and seizures while 9% of aging homozygotes develop tumors.
 
Human Diseases Modeled Using Mouse Dgkd (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Dgkd interacts with 270 markers (Mir7-1, Mir15a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process diacylglycerol metabolic process, phosphorylation, ...
Component cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function diacylglycerol kinase activity, protein heterodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (21)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 29
cDNA source data(198)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(200) cDNA(198) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000048195 (Evidence)
Ensembl Gene ModelENSMUSG00000070738 (Evidence)
Entrez Gene227333 (Evidence)
UniGene277217
DFCITC1670634, TC1600782, TC1597727, TC1575673, TC1675983
NIA Mouse Gene IndexU000570
EC2.7.1.107
Consensus CDS ProjectCCDS48312.1
International Mouse Knockout Project StatusDgkd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048195 VEGA Gene Model | MGI Sequence Detail 91894 C57BL/6J ±  kb
transcript OTTMUST00000123739 VEGA | MGI Sequence Detail 5695 Not Applicable 
polypeptide OTTMUSP00000067491 VEGA | MGI Sequence Detail 1220 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(14) UniProt(9)
Polymorphisms
SNPs within 2kb(329 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR000756 Diacylglycerol kinase, accessory domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000006444 diacylglycerol kinase delta
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:207242 Shulga YV, et al., Diacylglycerol kinase delta promotes lipogenesis. Biochemistry. 2013 Nov 5;52(44):7766-76
All references(35)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory