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Dgkd Gene Detail
Summary
  • Symbol
    Dgkd
  • Name
    diacylglycerol kinase, delta
  • Synonyms
    dgkd-2, DGKdelta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138334
    NCBI Gene: 227333
  • Gene Overview
    MyGene.info: DGKD
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:87853287-87945180 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      91894 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.44 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DGKD, diacylglycerol kinase delta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DGKD, diacylglycerol kinase delta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dgkd-2, DGKdelta
  • Links
    NCBI Gene ID: 8527
    neXtProt AC: NX_Q16760
    UniProt: Q16760

  • Chr Location
    2q37.1; chr2:233354507-233472098 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 100054
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DGKD
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Dgkd mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are born with open eyelids and reduced body size, develop respiratory distress and die within 24 hrs of birth. Half of mice homozygous for a hypomorphic gene trap allele exhibit abnormal epileptic discharges and seizureswhile 9% of aging homozygotes develop tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000048195 VEGA Gene Model | MGI Sequence Detail 91894 C57BL/6J ±  kb
    transcript OTTMUST00000123739 VEGA | MGI Sequence Detail 5695 Not Applicable  
    polypeptide OTTMUSP00000067491 VEGA | MGI Sequence Detail 1220 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      327 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR037607 Diacylglycerol kinase
      IPR000756 Diacylglycerol kinase, accessory domain
      IPR001206 Diacylglycerol kinase, catalytic domain
      IPR037606 Diacylglycerol kinase delta, SAM domain
      IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
      IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 203
      cDNA 200
      Primer pair 3

      Microarray probesets 7
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 2
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:245876 Rohacek AM, et al., ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory