Dgkd
Gene Detail

Symbol Name ID

Dgkd diacylglycerol kinase, delta MGI:2138334

Synonyms

dgkd-2, DGKdelta

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:87853287-87944489 bp, + strand From NCBI annotation of GRCm38   91203 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:100054  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dgkd

Human homologs

Human Homolog		DGKD, diacylglycerol kinase, delta 130kDa
NCBI Gene ID		8527
neXtProt AC		NX_Q16760
Human Synonyms		dgkd-2, DGKdelta
Human Chr (Location)		2q37.1; chr2:234263153-234380743 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(1) Gene trapped(5)
 

Mice homozygous for a null allele are born with open eyelids and reduced body size, develop respiratory distress and die within 24 hrs of birth. Half of mice homozygous for a hypomorphic gene trap allele exhibit abnormal epileptic discharges and seizures while 9% of aging homozygotes develop tumors.

 
Human Diseases Modeled Using Mouse Dgkd (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	diacylglycerol metabolic process, phosphorylation, ...
Component	cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function	diacylglycerol kinase activity, protein heterodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (21)    Images (3)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RT-PCR	29

cDNA source data(199)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(201) cDNA(199) Primer pair(2)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000070738 (Evidence)
Entrez Gene	227333 (Evidence)
UniGene	277217
DFCI	TC1575673, TC1597727, TC1600782, TC1670634, TC1675983
NIA Mouse Gene Index	U000570
Consensus CDS Project	CCDS48312.1
International Mouse Knockout Project Status	Dgkd

Sequences

Length	Strain/Species
genomic	227333	NCBI Gene Model | MGI Sequence Detail	91203	C57BL/6J
transcript	NM_177646	RefSeq | MGI Sequence Detail	5694	C57BL/6
polypeptide	NP_808314	RefSeq | MGI Sequence Detail	1220	C57BL/6

All sequences(28) RefSeq(2) UniProt(3)

Protein-related information

Resource	ID	Description
InterPro	IPR000756	Diacylglycerol kinase, accessory domain
InterPro	IPR001206	Diacylglycerol kinase, catalytic domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR011510	Sterile alpha motif, type 2
Protein Ontology	PR:000006444	diacylglycerol kinase delta

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:193212 Takeuchi M, et al., Diacylglycerol kinase delta1 transiently translocates to the plasma membrane in response to high glucose. Biochim Biophys Acta. 2012 Dec;1823(12):2210-6
All references(33)