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Dgkd
Gene Detail
 Symbol
Name
ID
Dgkd
diacylglycerol kinase, delta
MGI:2138334
Synonyms dgkd-2, DGKdelta
Feature Type protein coding gene
Genetic Map
Chromosome 1
44.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:87853287-87944489 bp, + strand
From NCBI annotation of GRCm38

  91203 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100054  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Dgkd

Human
homologs
Human Homolog DGKD, diacylglycerol kinase, delta 130kDa
NCBI Gene ID 8527
neXtProt AC  NX_Q16760
Human Synonyms  dgkd-2, DGKdelta
Human Chr (Location)  2q37.1; chr2:233354503-233472098 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Gene trapped(5) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are born with open eyelids and reduced body size, develop respiratory distress and die within 24 hrs of birth. Half of mice homozygous for a hypomorphic gene trap allele exhibit abnormal epileptic discharges and seizures while 9% of aging homozygotes develop tumors.
 
Human Diseases Modeled Using Mouse Dgkd (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process diacylglycerol metabolic process, phosphorylation, ...
Component cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function ATP binding, diacylglycerol kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (21)    Images (3)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RT-PCR 29
cDNA source data(198)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(200) cDNA(198) Primer pair(2)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000070738 (Evidence)
Entrez Gene227333 (Evidence)
UniGene277217
DFCITC1575673, TC1597727, TC1600782, TC1670634, TC1675983
NIA Mouse Gene IndexU000570
EC2.7.1.107
Consensus CDS ProjectCCDS48312.1
International Mouse Knockout Project StatusDgkd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 227333 NCBI Gene Model | MGI Sequence Detail 91203 C57BL/6J ±  kb
transcript NM_177646 RefSeq | MGI Sequence Detail 5694 C57BL/6 
polypeptide NP_808314 RefSeq | MGI Sequence Detail 1220 C57BL/6 

For the selected sequences
All sequences(40) RefSeq(14) UniProt(3)
Polymorphisms SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR000756 Diacylglycerol kinase, accessory domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000006444 diacylglycerol kinase delta
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:207242 Shulga YV, et al., Diacylglycerol kinase delta promotes lipogenesis. Biochemistry. 2013 Nov 5;52(44):7766-76
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory