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Phlpp1 Gene Detail
Summary
  • Symbol
    Phlpp1
  • Name
    PH domain and leucine rich repeat protein phosphatase 1
  • Synonyms
    mKIAA0606, Phlpp, Plekhe1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138327
    NCBI Gene: 98432
  • Gene Overview
    MyGene.info: PHLPP1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:106171869-106394245 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 49.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138327
protein coding gene Chr1:106171752-106394250 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016370
protein coding gene Chr1:108319320-108551281 (+)
A/J MGP_AJ_G0016354
protein coding gene Chr1:104527911-104748015 (+)
AKR/J MGP_AKRJ_G0016314
protein coding gene Chr1:107399103-107613574 (+)
BALB/cJ MGP_BALBcJ_G0016310
protein coding gene Chr1:104629456-104851574 (+)
C3H/HeJ MGP_C3HHeJ_G0016137
protein coding gene Chr1:107840817-108066705 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016769
protein coding gene Chr1:112461113-112688987 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014487
protein coding gene Chr1:98860981-99070362 (+)
CAST/EiJ MGP_CASTEiJ_G0015719
protein coding gene Chr1:106762376-106990479 (+)
CBA/J MGP_CBAJ_G0016110
protein coding gene Chr1:116304052-116542429 (+)
DBA/2J MGP_DBA2J_G0016215
protein coding gene Chr1:103599531-103818897 (+)
FVB/NJ MGP_FVBNJ_G0016216
protein coding gene Chr1:102542816-102766510 (+)
LP/J MGP_LPJ_G0016289
protein coding gene Chr1:109573808-109802551 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016242
protein coding gene Chr1:120740864-120978532 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016808
protein coding gene Chr1:107476626-107699328 (+)
PWK/PhJ MGP_PWKPhJ_G0015506
protein coding gene Chr1:102632821-102852197 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015291
protein coding gene Chr1:106141700-106373412 (+)
WSB/EiJ MGP_WSBEiJ_G0015782
protein coding gene Chr1:107313613-107536944 (+)



Homology
more
  • Human Ortholog
    PHLPP1, PH domain and leucine rich repeat protein phosphatase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PHLPP1, PH domain and leucine rich repeat protein phosphatase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PHLPP, PLEKHE1, PPM3A, SCOP
  • Links
    NCBI Gene ID: 23239
    neXtProt AC: NX_O60346
    UniProt: O60346

  • Chr Location
    18q21.33; chr18:62715439-62980443 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display impairment in the ability to stabilize the circadian period after light induced resetting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 98432 NCBI Gene Model | MGI Sequence Detail 222377 C57BL/6J ±  kb
transcript NM_133821 RefSeq | MGI Sequence Detail 6123 C57BL/6  
polypeptide Q8CHE4 UniProt | EBI | MGI Sequence Detail 1687 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 66

    Microarray probesets 3
References
more
  • Summaries
    All 50
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:250183 Nakano JJ, et al., SCOP/PHLPP1beta in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior. Sci Rep. 2016 Sep 19;6:33500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory