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Phlpp1 Gene Detail
Summary
  • Symbol
    Phlpp1
  • Name
    PH domain and leucine rich repeat protein phosphatase 1
  • Synonyms
    mKIAA0606, Phlpp, Plekhe1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138327
    NCBI Gene: 98432
  • Gene Overview
    MyGene.info: PHLPP1
Location & Maps
more
  • Sequence Map
    Chr1:106171752-106394250 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      222499 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 49.76 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PHLPP1, PH domain and leucine rich repeat protein phosphatase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PHLPP1, PH domain and leucine rich repeat protein phosphatase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PHLPP, PLEKHE1, PPM3A, SCOP
  • Links
    NCBI Gene ID: 23239
    neXtProt AC: NX_O60346

  • Chr Location
    18q21.33; chr18:62715439-62980443 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Phlpp1
  • Incidental Mutations
Mice homozygous for a null mutation display impairment in the ability to stabilize the circadian period after light induced resetting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021548 VEGA Gene Model | MGI Sequence Detail 222499 C57BL/6J ±  kb
transcript OTTMUST00000051100 VEGA | MGI Sequence Detail 6226 Not Applicable  
polypeptide OTTMUSP00000024002 VEGA | MGI Sequence Detail 1687 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1231 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 65

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:86755 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2002 Oct 31;9(5):179-88
  • Latest
    J:231241 Wen YA, et al., Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2013-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory