Phlpp1 MGI Mouse Gene Detail - MGI:2138327 - PH domain and leucine rich repeat protein phosphatase 1

Symbol

Phlpp1
Name

PH domain and leucine rich repeat protein phosphatase 1
Synonyms

mKIAA0606, Phlpp, Plekhe1

Feature Type

protein coding gene
IDs

MGI:2138327
NCBI Gene: 98432
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr1:106099599-106321975 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 49.76 cM
Mapping Data

2 experiments

SNPs within 2kb

1230 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138327	protein coding gene	Chr1:106099482-106321980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016370	protein coding gene	Chr1:108319320-108551281 (+)
A/J	MGP_AJ_G0016354	protein coding gene	Chr1:104527911-104748015 (+)
AKR/J	MGP_AKRJ_G0016314	protein coding gene	Chr1:107399103-107613574 (+)
BALB/cJ	MGP_BALBcJ_G0016310	protein coding gene	Chr1:104629456-104851574 (+)
C3H/HeJ	MGP_C3HHeJ_G0016137	protein coding gene	Chr1:107840817-108066705 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016769	protein coding gene	Chr1:112461113-112688987 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014487	protein coding gene	Chr1:98860981-99070362 (+)
CAST/EiJ	MGP_CASTEiJ_G0015719	protein coding gene	Chr1:106762376-106990479 (+)
CBA/J	MGP_CBAJ_G0016110	protein coding gene	Chr1:116304052-116542429 (+)
DBA/2J	MGP_DBA2J_G0016215	protein coding gene	Chr1:103599531-103818897 (+)
FVB/NJ	MGP_FVBNJ_G0016216	protein coding gene	Chr1:102542816-102766510 (+)
LP/J	MGP_LPJ_G0016289	protein coding gene	Chr1:109573808-109802551 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016242	protein coding gene	Chr1:120740864-120978532 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016808	protein coding gene	Chr1:107476626-107699328 (+)
PWK/PhJ	MGP_PWKPhJ_G0015506	protein coding gene	Chr1:102632821-102852197 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015291	protein coding gene	Chr1:106141700-106373412 (+)
WSB/EiJ	MGP_WSBEiJ_G0015782	protein coding gene	Chr1:107313613-107536944 (+)

Human Ortholog

PHLPP1, PH domain and leucine rich repeat protein phosphatase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHLPP1, PH domain and leucine rich repeat protein phosphatase 1
Synonyms

PHLPP, PLEKHE1, PPM3A, SCOP
Links

HGNC:20610

NCBI Gene ID: 23239

neXtProt AC: NX_O60346

UniProt: O60346
Chr Location

18q21.33; chr18:62715541-62980433 (+) GRCh38

MGI Vertebrate Homology

Phlpp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PHLPP1
Gene Tree

Phlpp1

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Phenotype Summary

7 phenotypes from 2 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

3 involving Phlpp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display impairment in the ability to stabilize the circadian period after light induced resetting.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

7
cDNA Data

66
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase phlpp1

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS48337.1

Ensembl

ENSMUSG00000044340 (Evidence)
NCBI Gene

98432

			Length	Strain/Species	Flank
genomic	98432	NCBI Gene Model \| MGI Sequence Detail	222377	C57BL/6J	± kb
transcript	NM_133821	RefSeq \| MGI Sequence Detail	6123	C57BL/6
polypeptide	Q8CHE4	UniProt \| EBI \| MGI Sequence Detail	1687	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012667 PH domain leucine-rich repeat-containing protein phosphatase

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001932 PPM-type phosphatase-like domain

IPR036457 PPM-type phosphatase-like domain superfamily

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All nucleic 66

cDNA 66

Microarray probesets 3

Summaries

All 65

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 32
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:342571 Weaver SR, et al., Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth. J Bone Miner Res. 2021 May;36(5):986-999

TSS for Phlpp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8292	Chr1:106099380-106099459 (+)	-179 bp
Tssr8293	Chr1:106099503-106099609 (+)	-43 bp
Tssr8294	Chr1:106099612-106099626 (+)	20 bp
Tssr8295	Chr1:106099627-106099641 (+)	35 bp
Tssr8296	Chr1:106106264-106106278 (+)	6,672 bp
Tssr8297	Chr1:106122169-106122172 (+)	22,572 bp
Tssr8298	Chr1:106129593-106129594 (+)	29,995 bp
Tssr8299	Chr1:106134301-106134303 (+)	34,703 bp
Tssr8300	Chr1:106139226-106139238 (+)	39,633 bp
Tssr8301	Chr1:106141391-106141415 (+)	41,804 bp
Tssr8302	Chr1:106142154-106142168 (+)	42,562 bp
Tssr8304	Chr1:106155910-106155921 (+)	56,317 bp
Tssr8305	Chr1:106158454-106158467 (+)	58,862 bp
Tssr8306	Chr1:106158533-106158545 (+)	58,940 bp
Tssr8307	Chr1:106158580-106158588 (+)	58,985 bp
Tssr8309	Chr1:106179588-106179606 (+)	79,998 bp
Tssr8310	Chr1:106244944-106244973 (+)	145,360 bp
Tssr8311	Chr1:106246368-106246380 (+)	146,775 bp
Tssr8312	Chr1:106246430-106246437 (+)	146,835 bp
Tssr8313	Chr1:106262269-106262310 (+)	162,691 bp
Tssr8314	Chr1:106297629-106297631 (+)	198,031 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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