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Trp53bp2
Gene Detail
Symbol

Name
ID
Trp53bp2
transformation related protein 53 binding protein 2
MGI:2138319
Synonyms
53BP2, ASPP2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
84.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:182409172-182462432 bp, + strand
From VEGA annotation of GRCm38

  53261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3959  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TP53BP2
Gene Tree: Trp53bp2

Human
homologs
TP53BP2, tumor protein p53 binding protein 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7159
neXtProt AC: NX_Q13625

Human Synonyms: 53BP2, ASPP2, BBP, P53BP2, PPP1R13A

Human Chr (Location): 1q41; chr1:223779893-223845981 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation is lethal by 30 days of age, although majority die embryonically. Heterozygotes show increased susceptibility to spontaneous and induced tumors of the lymphoma and sarcoma types
 
Interactions
Trp53bp2 interacts with 139 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process apoptotic process, cell cycle, ...
Component cytoplasm, nucleus, ...
Function identical protein binding, NF-kappaB binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (130)    Tissues (125)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
Northern blot 1
Western blot 3
RT-PCR 9
cDNA source data(101)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tp53bp2a, tp53bp2b    NEW 
Molecular
reagents
All nucleic(104) cDNA(101) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027043 (Evidence)
Ensembl Gene Model ENSMUSG00000026510 (Evidence)
Entrez Gene 209456 (Evidence)
UniGene 287450
DFCI TC1603618, TC1576622
DoTS DT.91578529, DT.97336597, DT.101702736, DT.101245191
NIA Mouse Gene Index U042242
Consensus CDS Project CCDS48476.1
International Mouse Phenotyping Consortium Status Trp53bp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027043 VEGA Gene Model | MGI Sequence Detail 53261 C57BL/6J ±  kb
transcript OTTMUST00000066841 VEGA | MGI Sequence Detail 4361 Not Applicable 
polypeptide OTTMUSP00000033553 VEGA | MGI Sequence Detail 1134 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(368 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR013315 Spectrin alpha chain, SH3 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000016559 apoptosis-stimulating of p53 protein 2
References
(Earliest) J:38063 Sowden JC, et al., The identification of novel sequences expressed in the mouse notochord. Mamm Genome. 1997 Jan;8(1):42-4
(Latest) J:201953 Tordella L, et al., ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17969-74
All references(41)
Other
accession IDs
MGI:2138737

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory