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Trp53bp2 Gene Detail
Summary
  • Symbol
    Trp53bp2
  • Name
    transformation related protein 53 binding protein 2
  • Synonyms
    53BP2, ASPP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138319
    NCBI Gene: 209456
  • Gene Overview
    MyGene.info: TP53BP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:182409172-182462432 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138319
protein coding gene Chr1:182409167-182462436 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016894
protein coding gene Chr1:189035967-189092796 (+)
A/J MGP_AJ_G0016873
protein coding gene Chr1:181330915-181385388 (+)
AKR/J MGP_AKRJ_G0016838
protein coding gene Chr1:186708423-186760884 (+)
BALB/cJ MGP_BALBcJ_G0016831
protein coding gene Chr1:181964717-182018759 (+)
C3H/HeJ MGP_C3HHeJ_G0016655
protein coding gene Chr1:187523398-187577574 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017294
protein coding gene Chr1:195138347-195193049 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015001
protein coding gene Chr1:172401708-172455639 (+)
CAST/EiJ MGP_CASTEiJ_G0016237
protein coding gene Chr1:186867170-186921038 (+)
CBA/J MGP_CBAJ_G0016629
protein coding gene Chr1:202368243-202436050 (+)
DBA/2J MGP_DBA2J_G0016735
protein coding gene Chr1:180109264-180162757 (+)
FVB/NJ MGP_FVBNJ_G0016731
protein coding gene Chr1:178240644-178299593 (+)
LP/J MGP_LPJ_G0016810
protein coding gene Chr1:190231002-190286524 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016763
protein coding gene Chr1:209388042-209443677 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017331
protein coding gene Chr1:186532889-186588948 (+)
PWK/PhJ MGP_PWKPhJ_G0016025
protein coding gene Chr1:179295796-179350245 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015801
protein coding gene Chr1:185488652-185547727 (+)
WSB/EiJ MGP_WSBEiJ_G0016300
protein coding gene Chr1:186726946-186782766 (+)



Homology
more
  • Human Ortholog
    TP53BP2, tumor protein p53 binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TP53BP2, tumor protein p53 binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    53BP2, ASPP2, BBP, P53BP2, PPP1R13A
  • Links
    NCBI Gene ID: 7159
    neXtProt AC: NX_Q13625
    UniProt: Q13625

  • Chr Location
    1q41; chr1:223779893-223845981 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Trp53bp2 mouse models

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 4 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation is lethal by 30 days of age, although majority die embryonically. Heterozygotes show increased susceptibility to spontaneous and induced tumors of the lymphoma and sarcoma types
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026510 Ensembl Gene Model | MGI Sequence Detail 53261 C57BL/6J ±  kb
    transcript ENSMUST00000117245 Ensembl | MGI Sequence Detail 4361 Not Applicable  
    polypeptide ENSMUSP00000112508 Ensembl | MGI Sequence Detail 1134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 102
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138737
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:38063 Sowden JC, et al., The identification of novel sequences expressed in the mouse notochord. Mamm Genome. 1997 Jan;8(1):42-4
    • Latest
      J:241720 Van Hook K, et al., DeltaN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1271-1277

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory