About   Help   FAQ
D2hgdh
Gene Detail
Symbol

Name
ID
D2hgdh
D-2-hydroxyglutarate dehydrogenase
MGI:2138209
Feature Type
protein coding gene
Genetic Map
Chromosome 1
47.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:93824909-93852348 bp, + strand
From VEGA annotation of GRCm38

  27440 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glycolate oxidase chain GlcD
Gene Tree: D2hgdh

Human
homologs
Human Homolog D2HGDH, D-2-hydroxyglutarate dehydrogenase
NCBI Gene ID 728294
neXtProt AC  NX_Q8N465
Human Synonyms  D2HGD
Human Chr (Location)  2q37.3; chr2:241734579-241768816 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human D2HGDH
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
D2hgdh interacts with 193 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular protein metabolic process, oxidation-reduction process, ...
Component mitochondrion
Function catalytic activity, flavin adenine dinucleotide binding, ...
External Resources: FuncBase
Expression
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(46)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021837 (Evidence)
Ensembl Gene ModelENSMUSG00000073609 (Evidence)
Entrez Gene98314 (Evidence)
UniGene383401
DFCITC1581303, TC1633204, TC1657553, TC1729493
EC1.1.99.-
Consensus CDS ProjectCCDS15196.1
International Mouse Knockout Project StatusD2hgdh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021837 VEGA Gene Model | MGI Sequence Detail 27440 C57BL/6J ±  kb
transcript OTTMUST00000051830 VEGA | MGI Sequence Detail 3459 Not Applicable 
polypeptide OTTMUSP00000024460 VEGA | MGI Sequence Detail 557 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)    SNPs within 2kb including multiple locations(219)
Protein-related
information
ResourceIDDescription
InterPro IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro IPR016166 FAD-binding, type 2
InterPro IPR016167 FAD-binding, type 2, subdomain 1
InterPro IPR004113 FAD-linked oxidase, C-terminal
InterPro IPR016164 FAD-linked oxidase-like, C-terminal
InterPro IPR006094 FAD linked oxidase, N-terminal
InterPro IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2
Protein Ontology PR:000006254 D-2-hydroxyglutarate dehydrogenase, mitochondrial
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(30)
Other
accession IDs
MGI:2138084, MGI:2138085

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory