D2hgdh
Gene Detail

Symbol Name ID

D2hgdh D-2-hydroxyglutarate dehydrogenase MGI:2138209

Feature Type

protein coding gene

Genetic Map

Chromosome 1

47.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:93825240-93852348 bp, + strand From VEGA annotation of GRCm38   27109 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycolate oxidase chain GlcD
Gene Tree: D2hgdh

Human homologs

Human Homolog		D2HGDH, D-2-hydroxyglutarate dehydrogenase
NCBI Gene ID		728294
neXtProt AC		NX_Q8N465
Human Synonyms		D2HGD
Human Chr (Location)		2q37.3; chr2:242674030-242708231 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human D2HGDH

Alleles and phenotypes

All alleles(4) : Targeted(1) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cellular protein metabolic process, oxidation-reduction process, ...
Component	mitochondrion
Function	catalytic activity, flavin adenine dinucleotide binding, ...

External Resources: FuncBase

Expression

cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) cDNA(46)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021837 (Evidence)
Ensembl Gene Model	ENSMUSG00000073609 (Evidence)
Entrez Gene	98314 (Evidence)
UniGene	383401
DFCI	TC1581303, TC1633204, TC1657553, TC1729493
EC	1.1.99.-
Consensus CDS Project	CCDS15196.1
International Mouse Knockout Project Status	D2hgdh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021837	VEGA Gene Model | MGI Sequence Detail	27109	C57BL/6J
transcript	OTTMUST00000051830	VEGA | MGI Sequence Detail	3459	Not Applicable
polypeptide	OTTMUSP00000024460	VEGA | MGI Sequence Detail	557	Not Applicable

All sequences(38) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(50 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016169	CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro	IPR016166	FAD-binding, type 2
InterPro	IPR016167	FAD-binding, type 2, subdomain 1
InterPro	IPR004113	FAD-linked oxidase, C-terminal
InterPro	IPR016164	FAD-linked oxidase-like, C-terminal
InterPro	IPR006094	FAD linked oxidase, N-terminal
InterPro	IPR016171	Vanillyl-alcohol oxidase, C-terminal subdomain 2
Protein Ontology	PR:000006254	D-2-hydroxyglutarate dehydrogenase, mitochondrial

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(29)

Other accession IDs

MGI:2138084, MGI:2138085