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D2hgdh Gene Detail
Summary
  • Symbol
    D2hgdh
  • Name
    D-2-hydroxyglutarate dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138209
    NCBI Gene: 98314
  • Gene Overview
    MyGene.info: D2HGDH
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93824909-93852348 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 47.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138209
protein coding gene Chr1:93824808-93853857 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016351
protein coding gene Chr1:95472833-95474381 (+)
A/J MGP_AJ_G0016332
protein coding gene Chr1:92056488-92081762 (+)
AKR/J MGP_AKRJ_G0016293
protein coding gene Chr1:94769696-94802990 (+)
BALB/cJ MGP_BALBcJ_G0016288
protein coding gene Chr1:92237541-92272621 (+)
C3H/HeJ MGP_C3HHeJ_G0016117
protein coding gene Chr1:95025984-95216356 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016747
protein coding gene Chr1:99099991-99238465 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014465
protein coding gene Chr1:86297601-86320363 (+)
CAST/EiJ MGP_CASTEiJ_G0015700
protein coding gene Chr1:94357244-94515380 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0016267
protein coding gene Chr1:96654686-96697620 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016220
protein coding gene Chr1:105396488-105593950 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016786
protein coding gene Chr1:94802381-94947262 (+)
PWK/PhJ MGP_PWKPhJ_G0015485
protein coding gene Chr1:90687059-90700026 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015269
protein coding gene Chr1:93739209-93762498 (+)
WSB/EiJ MGP_WSBEiJ_G0015760
protein coding gene Chr1:94617452-94642997 (+)



Homology
more
  • Human Ortholog
    D2HGDH, D-2-hydroxyglutarate dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    D2HGDH, D-2-hydroxyglutarate dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D2HGD
  • Links
    NCBI Gene ID: 728294
    neXtProt AC: NX_Q8N465
    UniProt: Q8N465

  • Chr Location
    2q37.3; chr2:241734579-241768816 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human D2HGDH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073609 Ensembl Gene Model | MGI Sequence Detail 27440 C57BL/6J ±  kb
transcript ENSMUST00000112881 Ensembl | MGI Sequence Detail 3459 Not Applicable  
polypeptide ENSMUSP00000108502 Ensembl | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138084, MGI:2138085
References
more
  • Summaries
    All 35
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory