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Hmgn3 Gene Detail
Summary
  • Symbol
    Hmgn3
  • Name
    high mobility group nucleosomal binding domain 3
  • Synonyms
    1110002A15Rik, 6330514M13Rik, HMGN3a, HMGN3b, TRIP7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138069
    NCBI Gene: 94353
  • Gene Overview
    MyGene.info: HMGN3
Location & Maps
more
  • Sequence Map
    Chr9:83109948-83146685 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36738 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 45.29 cM, cytoband E3.1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HMGN3, high mobility group nucleosomal binding domain 3
  • Human Ortholog
    HMGN3, high mobility group nucleosomal binding domain 3
    Orthology source: HGNC
  • Synonyms
    PNAS-24, PNAS-25, TRIP7
  • Links
    NCBI Gene ID: 9324
    neXtProt AC: NX_Q15651

  • Chr Location
    6q14.1; chr6:79201245-79234738 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Hmgn3
  • Incidental Mutations
Mice homozygous for a null allele exhibit impaired glucose tolerance with decreased insulin serum levels and increased glucose serum levels during feeding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034786 VEGA Gene Model | MGI Sequence Detail 36738 C57BL/6J ±  kb
transcript OTTMUST00000088419 VEGA | MGI Sequence Detail 855 Not Applicable  
polypeptide OTTMUSP00000065951 VEGA | MGI Sequence Detail 128 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    297 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000029547 high mobility group nucleosome-binding domain-containing protein 3
  • InterPro Domains
    IPR000079 High mobility group protein HMGN
    IPR031073 High mobility group protein HMGN3
Molecular
Reagents
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  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1914636, MGI:1923404, MGI:2143355
References
more
  • Summaries
    All 39
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory