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Sfxn3 Gene Detail
Summary
  • Symbol
    Sfxn3
  • Name
    sideroflexin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137679
    NCBI Gene: 94280
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45047576-45056383 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.26 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137679
protein coding gene Chr19:45047241-45056383 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025183
protein coding gene Chr19:44592563-44602868 (+)
A/J MGP_AJ_G0025160
protein coding gene Chr19:42446055-42454855 (+)
AKR/J MGP_AKRJ_G0025128
protein coding gene Chr19:43808300-43817314 (+)
BALB/cJ MGP_BALBcJ_G0025154
protein coding gene Chr19:42497959-42507191 (+)
C3H/HeJ MGP_C3HHeJ_G0024914
protein coding gene Chr19:43969515-43985730 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025597
protein coding gene Chr19:45681867-45693290 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023011
protein coding gene Chr19:41713488-41722444 (+)
CAST/EiJ MGP_CASTEiJ_G0024379
protein coding gene Chr19:43713154-43723413 (+)
CBA/J MGP_CBAJ_G0024894
protein coding gene Chr19:48000006-48012021 (+)
DBA/2J MGP_DBA2J_G0025026
protein coding gene Chr19:42265900-42274696 (+)
FVB/NJ MGP_FVBNJ_G0024987
protein coding gene Chr19:42032463-42041244 (+)
LP/J MGP_LPJ_G0025112
protein coding gene Chr19:44535144-44543892 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025018
protein coding gene Chr19:47385961-47394901 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025655
protein coding gene Chr19:43887590-43896390 (+)
PWK/PhJ MGP_PWKPhJ_G0024128
protein coding gene Chr19:42173003-42181767 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023932
protein coding gene Chr19:42577934-42586734 (+)
WSB/EiJ MGP_WSBEiJ_G0024449
protein coding gene Chr19:44029925-44040218 (+)



Homology
more
  • Human Ortholog
    SFXN3, sideroflexin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SFXN3, sideroflexin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BA108L7.2, SFX3, SLC56A3
  • Links
    NCBI Gene ID: 81855
    neXtProt AC: NX_Q9BWM7
    UniProt: Q9BWM7

  • Chr Location
    10q24.31; chr10:101031229-101041243 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal mitochondrial bioenergetics in isolated synaptosomes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025212 Ensembl Gene Model | MGI Sequence Detail 8808 C57BL/6J ±  kb
transcript ENSMUST00000062213 Ensembl | MGI Sequence Detail 2966 Not Applicable  
polypeptide ENSMUSP00000059419 Ensembl | MGI Sequence Detail 321 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 78
    cDNA 78

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:68377 Fleming MD, et al., A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev. 2001 Mar 15;15(6):652-7
  • Latest
    J:240628 Amorim IS, et al., Sideroflexin 3 is an alpha-synuclein-dependent mitochondrial protein that regulates synaptic morphology. J Cell Sci. 2017 Jan 15;130(2):325-331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory