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Zfhx4 Gene Detail
Summary
  • Symbol
    Zfhx4
  • Name
    zinc finger homeodomain 4
  • Synonyms
    C130041O22Rik, Zfh4, Zfh-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137668
    NCBI Gene: 80892
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:5283586-5480917 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 1.96 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1318 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137668
protein coding gene Chr3:5276268-5480921 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027045
protein coding gene Chr3:1976127-2187063 (+)
A/J MGP_AJ_G0027009
protein coding gene Chr3:2355733-2554926 (+)
AKR/J MGP_AKRJ_G0026979
protein coding gene Chr3:2139328-2336318 (+)
BALB/cJ MGP_BALBcJ_G0027018
protein coding gene Chr3:2054514-2264324 (+)
C3H/HeJ MGP_C3HHeJ_G0026758
protein coding gene Chr3:2361786-2576100 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027463
protein coding gene Chr3:2455002-2654440 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024825
protein coding gene Chr3:1650122-1851228 (+)
CAST/EiJ MGP_CASTEiJ_G0026217
protein coding gene Chr3:2441612-2650865 (+)
CBA/J MGP_CBAJ_G0026737
protein coding gene Chr3:2178865-2393529 (+)
DBA/2J MGP_DBA2J_G0026872
protein coding gene Chr3:1955612-2157572 (+)
FVB/NJ MGP_FVBNJ_G0026839
protein coding gene Chr3:1897503-2094014 (+)
LP/J MGP_LPJ_G0026983
protein coding gene Chr3:2510596-2725767 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026859
protein coding gene Chr3:2792323-3036486 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027522
protein coding gene Chr3:1946676-2148064 (+)
PWK/PhJ MGP_PWKPhJ_G0025952
protein coding gene Chr3:2223907-2426409 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025754
protein coding gene Chr3:2105852-2318240 (+)
WSB/EiJ MGP_WSBEiJ_G0026288
protein coding gene Chr3:1982077-2189605 (+)



Homology
more
  • Human Ortholog
    ZFHX4, zinc finger homeobox 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFHX4, zinc finger homeobox 4
  • Synonyms
    ZFH4, ZHF4
  • Links
    NCBI Gene ID: 79776
    neXtProt AC: NX_Q86UP3
    UniProt: Q86UP3

  • Chr Location
    8q21.13; chr8:76681219-76867285 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025255 Ensembl Gene Model | MGI Sequence Detail 197332 C57BL/6J ±  kb
    transcript ENSMUST00000175866 Ensembl | MGI Sequence Detail 11287 Not Applicable  
    polypeptide ENSMUSP00000135827 Ensembl | MGI Sequence Detail 3606 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442583
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 18
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:22813 Kostich WA, et al., Expression of zfh-4, a new member of the zinc finger-homeodomain family, in developing brain and muscle. Dev Dyn. 1995 Feb;202(2):145-52
    • Latest
      J:321501 Wang W, et al., The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development. Nat Commun. 2022 Feb 17;13(1):958

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/22/2022
    MGI 6.22
    The Jackson Laboratory