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Zfhx4 Gene Detail
Summary
  • Symbol
    Zfhx4
  • Name
    zinc finger homeodomain 4
  • Synonyms
    C130041O22Rik, Zfh4, Zfh-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137668
    NCBI Gene: 80892
Location & Maps
more
  • Sequence Map
    Chr3:5218526-5415857 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      197332 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 1.96 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZFHX4, zinc finger homeobox 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFHX4, zinc finger homeobox 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ZFH4, ZHF4
  • Links
    NCBI Gene ID: 79776
    neXtProt AC: NX_Q86UP3

  • Chr Location
    8q21.11; chr8:76681219-76867285 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23477
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ZFHX4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ZFHX4 associations

Human Disease Mouse Models
       Ptosis, Hereditary Congenital 1; PTOS1   OMIM: 178300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000041080 VEGA Gene Model | MGI Sequence Detail 197332 C57BL/6J ±  kb
transcript OTTMUST00000107193 VEGA | MGI Sequence Detail 11287 Not Applicable  
polypeptide OTTMUSP00000059857 VEGA | MGI Sequence Detail 3606 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1318 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2442583
References
more
  • Summaries
    All 31
    Developmental Gene Expression 11
    Gene Ontology 3
  • Earliest
    J:22813 Kostich WA, et al., Expression of zfh-4, a new member of the zinc finger-homeodomain family, in developing brain and muscle. Dev Dyn. 1995 Feb;202(2):145-52
  • Latest
    J:208791 Chudnovsky Y, et al., ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Rep. 2014 Jan 30;6(2):313-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory