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Zfhx4
Gene Detail
Symbol

Name
ID
Zfhx4
zinc finger homeodomain 4
MGI:2137668
Synonyms
C130041O22Rik, Zfh4, Zfh-4
Feature Type
protein coding gene
Genetic Map
Chromosome 3
1.96 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:5218526-5415857 bp, + strand
From VEGA annotation of GRCm38

  197332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZFHX4
Gene Tree: Zfhx4

Human
homologs
ZFHX4, zinc finger homeobox 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79776
neXtProt AC: NX_Q86UP3

Human Synonyms: ZFH4, ZHF4

Human Chr (Location): 8q21.11; chr8:76681219-76867285 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ZFHX4

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Zfhx4 interacts with 529 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (115)    Tissues (76)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
RT-PCR 17
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ZFHX4 ; Xenbase zfhx4 ; ZFIN zfhx4    NEW 
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000041080 (Evidence)
Ensembl Gene Model ENSMUSG00000025255 (Evidence)
Entrez Gene 80892 (Evidence)
DFCI TC1581974, TC1597912, TC1617580, TC1627903
DoTS DT.525552
PDB 2YRK
Consensus CDS Project CCDS38382.1
International Mouse Phenotyping Consortium Status Zfhx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000041080 VEGA Gene Model | MGI Sequence Detail 197332 C57BL/6J ±  kb
transcript OTTMUST00000107193 VEGA | MGI Sequence Detail 11287 Not Applicable 
polypeptide OTTMUSP00000059857 VEGA | MGI Sequence Detail 3606 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(1324 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1326)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
InterPro IPR003604 Zinc finger, U1-type
Protein Ontology PR:000017629 zinc finger homeobox protein 4
References
(Earliest) J:22813 Kostich WA, et al., Expression of zfh-4, a new member of the zinc finger-homeodomain family, in developing brain and muscle. Dev Dyn. 1995 Feb;202(2):145-52
(Latest) J:208791 Chudnovsky Y, et al., ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Rep. 2014 Jan 30;6(2):313-24
All references(33)
Other
accession IDs
MGI:2442583

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory