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Pkmyt1 Gene Detail
Summary
  • Symbol
    Pkmyt1
  • Name
    protein kinase, membrane associated tyrosine/threonine 1
  • Synonyms
    Myt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137630
    NCBI Gene: 268930
  • Gene Overview
    MyGene.info: PKMYT1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:23726336-23736729 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.02 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137630
protein coding gene Chr17:23726336-23736735 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023267
protein coding gene Chr17:22642050-22653664 (+)
A/J MGP_AJ_G0023227
protein coding gene Chr17:21987927-21998282 (+)
AKR/J MGP_AKRJ_G0023197
protein coding gene Chr17:22068725-22078983 (+)
BALB/cJ MGP_BALBcJ_G0023232
protein coding gene Chr17:22205391-22215726 (+)
C3H/HeJ MGP_C3HHeJ_G0022992
protein coding gene Chr17:22426746-22437823 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023675
protein coding gene Chr17:23631575-23641974 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021156
protein coding gene Chr17:19554186-19564862 (+)
CAST/EiJ MGP_CASTEiJ_G0022498
protein coding gene Chr17:22257681-22269658 (+)
CBA/J MGP_CBAJ_G0022968
protein coding gene Chr17:24433997-24444493 (+)
DBA/2J MGP_DBA2J_G0023100
protein coding gene Chr17:21617962-21629003 (+)
FVB/NJ MGP_FVBNJ_G0023067
protein coding gene Chr17:21342439-21353250 (+)
LP/J MGP_LPJ_G0023174
protein coding gene Chr17:22894531-22904872 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023086
protein coding gene Chr17:24196251-24206483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023714
protein coding gene Chr17:22363862-22375485 (+)
PWK/PhJ MGP_PWKPhJ_G0022246
protein coding gene Chr17:20404996-20415542 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022066
protein coding gene Chr17:20382522-20392939 (+)
WSB/EiJ MGP_WSBEiJ_G0022561
protein coding gene Chr17:22415054-22425455 (+)



Homology
more
  • Human Ortholog
    PKMYT1, protein kinase, membrane associated tyrosine/threonine 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PKMYT1, protein kinase, membrane associated tyrosine/threonine 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MYT1, PPP1R126
  • Links
    NCBI Gene ID: 9088
    neXtProt AC: NX_Q99640
    UniProt: Q99640

  • Chr Location
    16p13.3; chr16:2972791-2980539 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023908 Ensembl Gene Model | MGI Sequence Detail 10394 C57BL/6J ±  kb
transcript ENSMUST00000024701 Ensembl | MGI Sequence Detail 2040 Not Applicable  
polypeptide ENSMUSP00000024701 Ensembl | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
    IPR016235 Tyrosine/threonine-protein kinase, Cdc2 inhibitor
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147053
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory