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Fkbp6 Gene Detail
Summary
  • Symbol
    Fkbp6
  • Name
    FK506 binding protein 6
  • Synonyms
    1700008G22Rik, D5Ertd724e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137612
    NCBI Gene: 94244
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135291704-135350044 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.11 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    329 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137612
protein coding gene Chr5:135291704-135351810 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030179
protein coding gene Chr5:139812636-139871599 (-)
A/J MGP_AJ_G0030147
protein coding gene Chr5:133825514-133884046 (-)
AKR/J MGP_AKRJ_G0030080
protein coding gene Chr5:138174238-138234690 (-)
BALB/cJ MGP_BALBcJ_G0030157
protein coding gene Chr5:135181912-135240245 (-)
C3H/HeJ MGP_C3HHeJ_G0029873
protein coding gene Chr5:138743090-138803869 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030610
protein coding gene Chr5:145031101-145091552 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027833
protein coding gene Chr5:128123133-128183513 (-)
CAST/EiJ MGP_CASTEiJ_G0029282
protein coding gene Chr5:138152253-138213798 (-)
CBA/J MGP_CBAJ_G0029843
protein coding gene Chr5:150723075-150787411 (-)
DBA/2J MGP_DBA2J_G0029994
protein coding gene Chr5:133721204-133795042 (-)
FVB/NJ MGP_FVBNJ_G0029949
protein coding gene Chr5:132858166-132921373 (-)
LP/J MGP_LPJ_G0030082
protein coding gene Chr5:140264876-140327375 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029981
protein coding gene Chr5:153723114-153784303 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030650
protein coding gene Chr5:137921849-137979326 (-)
PWK/PhJ MGP_PWKPhJ_G0028997
protein coding gene Chr5:132767482-132829016 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028832
protein coding gene Chr5:135484563-135545858 (-)
WSB/EiJ MGP_WSBEiJ_G0029356
protein coding gene Chr5:138669603-138734226 (-)



Homology
more
  • Human Ortholog
    FKBP6, FKBP prolyl isomerase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FKBP6, FKBP prolyl isomerase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKBP36
  • Links
    NCBI Gene ID: 8468
    neXtProt AC: NX_O75344
    UniProt: O75344

  • Chr Location
    7q11.23; chr7:73328152-73358637 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2672
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FKBP6
  • Gene Tree
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit azoospermia and male infertility associated with arrest of male meiosis at the pachytene stage, and increased apoptosis of meiotic spermatocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040013 Ensembl Gene Model | MGI Sequence Detail 58341 C57BL/6J ±  kb
    transcript ENSMUST00000201784 Ensembl | MGI Sequence Detail 1235 Not Applicable  
    polypeptide ENSMUSP00000144381 Ensembl | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007542 peptidyl-prolyl cis-trans isomerase FKBP6
    • InterPro Domains
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR013026 Tetratricopeptide repeat-containing domain
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 5
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1289148, MGI:1922705, MGI:2141034
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:30020 Coss MC, et al., Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65). J Biol Chem. 1995 Dec 8;270(49):29336-41
    • Latest
      J:216195 Segura-Puimedon M, et al., Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder. Hum Mol Genet. 2014 Dec 15;23(24):6481-94

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory