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Fkbp6
Gene Detail
 Symbol
Name
ID
Fkbp6
FK506 binding protein 6
MGI:2137612
Synonyms 1700008G22Rik, 36kDa, D5Ertd724e
Feature Type protein coding gene
Genetic Map
Chromosome 5
75.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:135291704-135349991 bp, - strand
From NCBI annotation of GRCm38

  58288 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2672  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fkbp6

Human
homologs
Human Homolog FKBP6, FK506 binding protein 6, 36kDa
NCBI Gene ID 8468
neXtProt AC  NX_O75344
Human Synonyms  FKBP36
Human Chr (Location)  7q11.23; chr7:73328152-73358637 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Fkbp6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this locus results in a complete block of spermatogenesis, apoptosis of meiotic spermatocytes, and consequent male infertility. Fertility and meiosis are normal in mutant female mice.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Fkbp6 interacts with 100 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, chaperone-mediated protein folding, ...
Component chromosome, cytoplasm, ...
Function FK506 binding, Hsp90 protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (2)   
Theiler Stages: 26, 28
Assay TypeResults
Immunohistochemistry 2
Western blot 2
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(5) cDNA(14) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000040013 (Evidence)
Entrez Gene94244 (Evidence)
UniGene26037
DFCITC1586717, TC1633293
DoTSDT.60102302, DT.87072305, DT.91326471, DT.94177717
NIA Mouse Gene IndexU026817
Consensus CDS ProjectCCDS19738.1
International Mouse Knockout Project StatusFkbp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 94244 NCBI Gene Model | MGI Sequence Detail 58288 C57BL/6J ±  kb
transcript NM_033571 RefSeq | MGI Sequence Detail 1447 C57BL/6 
polypeptide Q91XW8 UniProt | EBI | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(16) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(323 from dbSNP Build 137)    SNPs within 2kb including multiple locations(325)
Protein-related
information
ResourceIDDescription
InterPro IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000007542 peptidyl-prolyl cis-trans isomerase FKBP6
Graphical View of Protein Domain Structure
References (Earliest) J:30020 Coss MC, et al., Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65). J Biol Chem. 1995 Dec 8;270(49):29336-41
(Latest) J:188133 Xiol J, et al., A Role for Fkbp6 and the Chaperone Machinery in piRNA Amplification and Transposon Silencing. Mol Cell. 2012 Sep 28;47(6):970-9
All references(37)
Other
accession IDs
MGI:1289148, MGI:1922705, MGI:2141034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory