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Slc24a3 Gene Detail
Summary
  • Symbol
    Slc24a3
  • Name
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
  • Synonyms
    NCKX3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137513
    NCBI Gene: 94249
Location & Maps
more
  • Sequence Map
    Chr2:145167754-145642166 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      474413 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 71.08 cM, cytoband H1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC24A3, solute carrier family 24 member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC24A3, solute carrier family 24 member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NCKX3
  • Links
    NCBI Gene ID: 57419
    neXtProt AC: NX_Q9HC58

  • Chr Location
    20p13; chr20:19212646-19722897 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Slc24a3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004017 VEGA Gene Model | MGI Sequence Detail 474413 C57BL/6J ±  kb
transcript OTTMUST00000008923 VEGA | MGI Sequence Detail 4048 Not Applicable  
polypeptide OTTMUSP00000004359 VEGA | MGI Sequence Detail 645 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4798 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015000 sodium/potassium/calcium exchanger 3
  • InterPro Domains
    IPR004837 Sodium/calcium exchanger membrane region
    IPR004481 Sodium/potassium/calcium exchanger
    IPR030248 Sodium/potassium/calcium exchanger 3
Molecular
Reagents
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  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:70136 Kraev A, et al., Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3. J Biol Chem. 2001 Jun 22;276(25):23161-72
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory