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Bpifb1 Gene Detail
Summary
  • Symbol
    Bpifb1
  • Name
    BPI fold containing family B, member 1
  • Synonyms
    2310039C12Rik, LPlunc1, U46068, von Ebner minor salivary protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137431
    NCBI Gene: 228801
  • Gene Overview
    MyGene.info: BPIFB1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:154190818-154220343 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 76.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    480 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137431
protein coding gene Chr2:154190818-154220369 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026709
protein coding gene Chr2:158908422-158938808 (+)
A/J MGP_AJ_G0026675
protein coding gene Chr2:152515470-152552244 (+)
AKR/J MGP_AKRJ_G0026646
protein coding gene Chr2:157000293-157034316 (+)
BALB/cJ MGP_BALBcJ_G0026685
protein coding gene Chr2:152862314-152892340 (+)
C3H/HeJ MGP_C3HHeJ_G0026427
protein coding gene Chr2:157374723-157404214 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027134
protein coding gene Chr2:163532063-163561544 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024504
protein coding gene Chr2:146113642-146145132 (+)
CAST/EiJ MGP_CASTEiJ_G0025888
protein coding gene Chr2:157707396-157744702 (+)
CBA/J MGP_CBAJ_G0026406
protein coding gene Chr2:169530419-169562867 (+)
DBA/2J MGP_DBA2J_G0026541
protein coding gene Chr2:151773808-151804283 (+)
FVB/NJ MGP_FVBNJ_G0026507
protein coding gene Chr2:150184536-150216860 (+)
LP/J MGP_LPJ_G0026646
protein coding gene Chr2:159005176-159035126 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026529
protein coding gene Chr2:173559083-173588919 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027189
protein coding gene Chr2:156881799-156912404 (+)
PWK/PhJ MGP_PWKPhJ_G0025622
protein coding gene Chr2:151331993-151363977 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025425
protein coding gene Chr2:155827491-155864338 (+)
WSB/EiJ MGP_WSBEiJ_G0025958
protein coding gene Chr2:157797649-157828738 (+)



Homology
more
  • Human Ortholog
    BPIFB1, BPI fold containing family B member 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    BPIFB1, BPI fold containing family B member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf114, LPLUNC1
  • Links
    NCBI Gene ID: 92747
    neXtProt AC: NX_Q8TDL5
    UniProt: Q8TDL5

  • Chr Location
    20q11.21; chr20:33283135-33309878 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit strain background sensitive transmission ratio distortion and increased basal MUC5B production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 228801 NCBI Gene Model | MGI Sequence Detail 29526 C57BL/6J ±  kb
    transcript NM_001012392 RefSeq | MGI Sequence Detail 1690 Swiss Webster  
    polypeptide Q61114 UniProt | EBI | MGI Sequence Detail 474 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000009898 BPI fold-containing family B member 1
    • InterPro Domains
      IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamily
      IPR021193 BPI fold-containing family B member 1
      IPR032942 BPI/LBP/Plunc family
      IPR001124 Lipid-binding serum glycoprotein, C-terminal
      IPR017942 Lipid-binding serum glycoprotein, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 6
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:88670 Hou J, et al., Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily. Dev Dyn. 2004 Mar;229(2):373-9
    • Latest
      J:245692 Donoghue LJ, et al., Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1. Genetics. 2017 Oct;207(2):801-812

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory