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Mepe
Gene Detail
 Symbol
Name
ID
Mepe
matrix extracellular phosphoglycoprotein with ASARM motif (bone)
MGI:2137384
Synonyms OF45
Feature Type protein coding gene
Genetic Map
Chromosome 5
50.68 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:104325329-104338611 bp, + strand
From NCBI annotation of GRCm38

  13283 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Mepe

Human
homologs
Human Homolog MEPE, matrix extracellular phosphoglycoprotein
NCBI Gene ID 56955
neXtProt AC  NX_Q9NQ76
Human Synonyms  OF45
Human Chr (Location)  4q21.1; chr4:87821411-87846817 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have increased amounts of trabecular bone in their skeleton and undergo less age related bone loss. Otherwise, they display a normal phenotype.
 
Phenotype Images(1)
Interactions
Mepe interacts with 56 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process negative regulation of bone mineralization, skeletal system development
Component proteinaceous extracellular matrix
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (28)    Tissues (14)    Images (5)
Theiler Stages: 22, 28
Assay TypeResults
Immunohistochemistry 2
Northern blot 12
RT-PCR 14
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000053863 (Evidence)
Entrez Gene94111 (Evidence)
UniGene196672
DFCITC1588656
DoTSDT.94185552
NIA Mouse Gene IndexU005894
Consensus CDS ProjectCCDS51578.1
International Mouse Knockout Project StatusMepe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 94111 NCBI Gene Model | MGI Sequence Detail 13283 C57BL/6J ±  kb
transcript NM_053172 RefSeq | MGI Sequence Detail 1682 Not Specified 
polypeptide NP_444402 RefSeq | MGI Sequence Detail 441 Not Specified 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(418 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009837 Osteoregulin
Protein Ontology PR:000010327 matrix extracellular phosphoglycoprotein
References (Earliest) J:70223 Argiro L, et al., Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics. 2001 Jun 15;74(3):342-51
(Latest) J:186244 Staines KA, et al., MEPE is a novel regulator of growth plate cartilage mineralization. Bone. 2012 Sep;51(3):418-30
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory