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Mepe Gene Detail
Summary
  • Symbol
    Mepe
  • Name
    matrix extracellular phosphoglycoprotein with ASARM motif (bone)
  • Synonyms
    OF45
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137384
    NCBI Gene: 94111
  • Gene Overview
    MyGene.info: MEPE
Location & Maps
more
  • Sequence Map
    Chr5:104325329-104338611 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13283 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MEPE, matrix extracellular phosphoglycoprotein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MEPE, matrix extracellular phosphoglycoprotein
    Orthology source: HomoloGene
  • Synonyms
    OF45
  • Links
    NCBI Gene ID: 56955
    neXtProt AC: NX_Q9NQ76

  • Chr Location
    4q21.1; chr4:87821398-87846817 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    3 involving Mepe
  • Incidental Mutations
Mice homozygous for disruptions in this gene have increased amounts of trabecular bone in their skeleton and undergo less age related bone loss. Otherwise, they display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053774 VEGA Gene Model | MGI Sequence Detail 13283 C57BL/6J ±  kb
transcript OTTMUST00000133855 VEGA | MGI Sequence Detail 1682 Not Applicable  
polypeptide OTTMUSP00000071085 VEGA | MGI Sequence Detail 441 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    416 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR009837 Osteoregulin
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:70223 Argiro L, et al., Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics. 2001 Jun 15;74(3):342-51
  • Latest
    J:227060 Fujikawa K, et al., An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. Eur J Histochem. 2015;59(3):2553

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory