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Trim33 Gene Detail
Summary
  • Symbol
    Trim33
  • Name
    tripartite motif-containing 33
  • Synonyms
    8030451N04Rik, Ecto, ectodermin, mKIAA1113, Tif1g
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137357
    NCBI Gene: 94093
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:103186609-103266086 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1216 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137357
 protein coding gene Chr3:103186609-103266091 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027693
 protein coding gene Chr3:104540386-104635526 (+)
A/J MGP_AJ_G0027652
 protein coding gene Chr3:101216859-101296976 (+)
AKR/J MGP_AKRJ_G0027618
 protein coding gene Chr3:103700171-103787960 (+)
BALB/cJ MGP_BALBcJ_G0027665
 protein coding gene Chr3:100985274-101069959 (+)
C3H/HeJ MGP_C3HHeJ_G0027394
 protein coding gene Chr3:104034799-104130002 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028108
 protein coding gene Chr3:108421681-108512756 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025449
 protein coding gene Chr3:97364337-97438129 (+)
CAST/EiJ MGP_CASTEiJ_G0026851
 protein coding gene Chr3:103151961-103241468 (+)
CBA/J MGP_CBAJ_G0027369
 protein coding gene Chr3:112139476-112236903 (+)
DBA/2J MGP_DBA2J_G0027512
 protein coding gene Chr3:100466964-100547868 (+)
FVB/NJ MGP_FVBNJ_G0027480
 protein coding gene Chr3:98398986-98478502 (+)
LP/J MGP_LPJ_G0027619
 protein coding gene Chr3:105870076-105970492 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027509
 protein coding gene Chr3:118267111-118353385 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028163
 protein coding gene Chr3:103226716-103313131 (+)
PWK/PhJ MGP_PWKPhJ_G0026577
 protein coding gene Chr3:100222487-100303701 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026399
 protein coding gene Chr3:101311458-101395207 (+)
WSB/EiJ MGP_WSBEiJ_G0026930
 protein coding gene Chr3:103784131-103870850 (+)



Homology
more
  • Human Ortholog
    TRIM33, tripartite motif containing 33
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM33, tripartite motif containing 33
  • Synonyms
    DDH4, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
  • Links
    NCBI Gene ID: 51592
    UniProt: Q9UPN9

  • Chr Location
    1p13.2; chr1:114392790-114511203 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 6 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E9.5 with abnormal embryonic development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    59
  • cDNA Data
    128
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94093 NCBI Gene Model | MGI Sequence Detail 79478 C57BL/6J ±  kb
    transcript NM_053170 RefSeq | MGI Sequence Detail 8870 C57BL/6  
    polypeptide Q99PP7 UniProt | EBI | MGI Sequence Detail 1142 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      cDNA 128
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139690, MGI:2444632
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 12
      Phenotypes 49
    • Earliest
      J:69273 Reymond A, et al., The tripartite motif family identifies cell compartments. EMBO J. 2001 May 1;20(9):2140-51
    • Latest
      J:374966 Tiniakou I, et al., Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation. Sci Immunol. 2024 Apr 12;9(94):eadi1023
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory