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Trim33
Gene Detail
 Symbol
Name
ID
Trim33
tripartite motif-containing 33
MGI:2137357
Synonyms 8030451N04Rik, Ecto, ectodermin, mKIAA1113, Tif1g
Feature Type protein coding gene
Genetic Map
Chromosome 3
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:103279293-103358768 bp, + strand
From NCBI annotation of GRCm38

  79476 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9296  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Trim33

Human
homologs
Human Homolog TRIM33, tripartite motif containing 33
NCBI Gene ID 51592
neXtProt AC  NX_Q9UPN9
Human Synonyms  ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
Human Chr (Location)  1p13.1; chr1:114392777-114511160 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRIM33
Alleles
and
phenotypes
All alleles(32) : Gene trapped(25) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E9.5 with abnormal embryonic development.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process negative regulation of BMP signaling pathway, protein ubiquitination, ...
Component intracellular, intracellular membrane-bounded organelle, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (76)    Tissues (48)    Images (14)
Theiler Stages: 17, 21, 23, 28
Assay TypeResults
RNA in situ 76
cDNA source data(127)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(128) cDNA(127) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000033014 (Evidence)
Entrez Gene94093 (Evidence)
UniGene195036
DFCITC1576747, TC1597560, TC1614933, TC1697831, TC1719088
DoTSDT.101740211, DT.40146651, DT.491043, DT.87028428, DT.91446989
NIA Mouse Gene IndexU003664
EC6.3.2.-
Consensus CDS ProjectCCDS38573.1, CCDS38574.1
International Mouse Knockout Project StatusTrim33
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 94093 NCBI Gene Model | MGI Sequence Detail 79476 C57BL/6J ±  kb
transcript NM_053170 RefSeq | MGI Sequence Detail 8870 C57BL/6 
polypeptide Q99PP7 UniProt | EBI | MGI Sequence Detail 1142 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(5) UniProt(3)
Polymorphisms SNPs within 2kb(266 from dbSNP Build 137)    SNPs within 2kb including multiple locations(268)
Protein-related
information
ResourceIDDescription
InterPro IPR003649 B-box, C-terminal
InterPro IPR001487 Bromodomain
InterPro IPR000315 Zinc finger, B-box
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016655 E3 ubiquitin-protein ligase TRIM33
Graphical View of Protein Domain Structure
References (Earliest) J:69273 Reymond A, et al., The tripartite motif family identifies cell compartments. EMBO J. 2001 May 1;20(9):2140-51
(Latest) J:192451 Bai X, et al., TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol. 2013 Jan 15;373(2):422-30
All references(52)
Other
accession IDs
MGI:2139690, MGI:2444632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory