Trim33
Gene Detail

Symbol Name ID

Trim33 tripartite motif-containing 33 MGI:2137357

Synonyms

8030451N04Rik, Ecto, ectodermin, mKIAA1113, Tif1g

Feature Type

protein coding gene

Genetic Map

Chromosome 3

45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:103279293-103358768 bp, + strand From NCBI annotation of GRCm38   79476 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9296  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Trim33

Human homologs

Human Homolog		TRIM33, tripartite motif containing 33
NCBI Gene ID		51592
neXtProt AC		NX_Q9UPN9
Human Synonyms		ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA
Human Chr (Location)		1p13.1; chr1:114935399-115053781 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TRIM33

Alleles and phenotypes

All alleles(32) : Targeted(7) Gene trapped(25)
 

Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E9.5 with abnormal embryonic development.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	negative regulation of BMP signaling pathway, protein ubiquitination, ...
Component	intracellular, intracellular membrane-bounded organelle, ...
Function	co-SMAD binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (76)    Tissues (48)    Images (14)
Theiler Stages: 17, 21, 23, 28

Assay Type	Results
RNA in situ	76

cDNA source data(120)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(121) cDNA(120) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000033014 (Evidence)
Entrez Gene	94093 (Evidence)
UniGene	195036
DFCI	TC1576747, TC1597560, TC1614933, TC1697831, TC1719088
DoTS	DT.101740211, DT.40146651, DT.491043, DT.87028428, DT.91446989
NIA Mouse Gene Index	U003664
EC	6.3.2.-
Consensus CDS Project	CCDS38573.1, CCDS38574.1
International Mouse Knockout Project Status	Trim33

Sequences

Length	Strain/Species
genomic	94093	NCBI Gene Model | MGI Sequence Detail	79476	C57BL/6J
transcript	NM_053170	RefSeq | MGI Sequence Detail	8868	C57BL/6
polypeptide	Q99PP7	UniProt | EBI | MGI Sequence Detail	1142	Not Applicable

All sequences(42) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(157 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003649	B-box, C-terminal
InterPro	IPR001487	Bromodomain
InterPro	IPR000315	Zinc finger, B-box
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
Protein Ontology	PR:000016655	E3 ubiquitin-protein ligase TRIM33

Graphical View of Protein Domain Structure

References

(Earliest) J:69273 Reymond A, et al., The tripartite motif family identifies cell compartments. EMBO J. 2001 May 1;20(9):2140-51
(Latest) J:192451 Bai X, et al., TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol. 2013 Jan 15;373(2):422-30
All references(51)

Other accession IDs

MGI:2139690, MGI:2444632