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Trim6 Gene Detail
Summary
  • Symbol
    Trim6
  • Name
    tripartite motif-containing 6
  • Synonyms
    C430046K18Rik, D7Ertd684e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137352
    NCBI Gene: 94088
  • Gene Overview
    MyGene.info: TRIM6
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:104218793-104235152 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 55.55 cM, cytoband F1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137352
protein coding gene Chr7:104218782-104235152 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032708
protein coding gene Chr7:107446639-107461629 (+)
A/J MGP_AJ_G0032683
protein coding gene Chr7:104636449-104651423 (+)
AKR/J MGP_AKRJ_G0032616
protein coding gene Chr7:107159082-107174310 (+)
BALB/cJ MGP_BALBcJ_G0032693
protein coding gene Chr7:104369347-104384367 (+)
C3H/HeJ MGP_C3HHeJ_G0032404
protein coding gene Chr7:107516578-107532861 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033189
protein coding gene Chr7:111474602-111504219 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030184
protein coding gene Chr7:106714205-106727447 (+)
CAST/EiJ MGP_CASTEiJ_G0031733
protein coding gene Chr7:99162586-99190040 (+)
CBA/J MGP_CBAJ_G0032372
protein coding gene Chr7:115421537-115440010 (+)
DBA/2J MGP_DBA2J_G0032526
protein coding gene Chr7:102969043-102984246 (+)
FVB/NJ MGP_FVBNJ_G0032479
protein coding gene Chr7:102677574-102693693 (+)
LP/J MGP_LPJ_G0032619
protein coding gene Chr7:108776059-108794933 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032513
protein coding gene Chr7:116803947-116820365 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033216
protein coding gene Chr7:106361295-106378600 (+)
PWK/PhJ MGP_PWKPhJ_G0031447
protein coding gene Chr7:95960485-95975862 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031292
protein coding gene Chr7:93579407-93603225 (+)
WSB/EiJ MGP_WSBEiJ_G0031848
protein coding gene Chr7:107101355-107121549 (+)



Homology
more
  • Human Ortholog
    TRIM6, tripartite motif containing 6
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TRIM6, tripartite motif containing 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RNF89
  • Links
    NCBI Gene ID: 117854
    neXtProt AC: NX_Q9C030
    UniProt: Q9C030

  • Chr Location
    11p15.4; chr11:5596101-5612958 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000072244 Ensembl Gene Model | MGI Sequence Detail 16360 C57BL/6J ±  kb
transcript ENSMUST00000098180 Ensembl | MGI Sequence Detail 3827 Not Applicable  
polypeptide ENSMUSP00000095782 Ensembl | MGI Sequence Detail 488 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1289200, MGI:1924853
References
more
  • Summaries
    All 48
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:222665 Rajsbaum R, et al., Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated antiviral response. Immunity. 2014 Jun 19;40(6):880-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory