About   Help   FAQ
Baiap2
Gene Detail
Symbol

Name
ID
Baiap2
brain-specific angiogenesis inhibitor 1-associated protein 2
MGI:2137336
Synonyms
IRSp53
Feature Type
protein coding gene
Genetic Map
Chromosome 11
83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:119942763-120006782 bp, + strand
From VEGA annotation of GRCm38

  64020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9697  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: BAIAP2
Gene Tree: Baiap2

Human
homologs
BAIAP2, BAI1-associated protein 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10458
neXtProt AC: NX_Q9UQB8

Human Synonyms: BAP2, FLAF3, IRSP53

Human Chr (Location): 17q25; chr17:81035144-81117432 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice show enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory.
 
Interactions
Baiap2 interacts with 255 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process actin crosslink formation, actin filament bundle assembly, ...
Component actin cytoskeleton, cell projection, ...
Function cytoskeletal adaptor activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (79)    Tissues (45)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 76
RT-PCR 3
cDNA source data(112)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase baiap2    NEW 
Molecular
reagents
All nucleic(113) cDNA(112) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000004049 (Evidence)
Ensembl Gene Model ENSMUSG00000025372 (Evidence)
Entrez Gene 108100 (Evidence)
UniGene 197534
DFCI TC1724213, TC1595551, TC1592503, TC1579861, TC1573195
DoTS DT.91343408, DT.101349137, DT.101707294, DT.101386906, DT.94299066, DT.97341455, DT.99866458
NIA Mouse Gene Index U013649
Consensus CDS Project CCDS25722.1, CCDS25723.1, CCDS25724.1
International Mouse Phenotyping Consortium Status Baiap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004049 VEGA Gene Model | MGI Sequence Detail 64020 C57BL/6J ±  kb
transcript OTTMUST00000009018 VEGA | MGI Sequence Detail 2394 Not Applicable 
polypeptide OTTMUSP00000004381 VEGA | MGI Sequence Detail 535 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(14) UniProt(4)
Polymorphisms
SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013606 IRSp53/MIM homology domain (IMD)
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004632 brain-specific angiogenesis inhibitor 1-associated protein 2
References
(Earliest) J:62164 Fujiwara T, et al., Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. Biochem Biophys Res Commun. 2000 May 19;271(3):626-9
(Latest) J:202460 Disanza A, et al., CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP. EMBO J. 2013 Oct 16;32(20):2735-50
All references(52)
Other
accession IDs
MGI:2144701

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory