Baiap2
Gene Detail

Symbol Name ID

Baiap2 brain-specific angiogenesis inhibitor 1-associated protein 2 MGI:2137336

Synonyms

IRSp53

Feature Type

protein coding gene

Genetic Map

Chromosome 11

83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:119942763-120006782 bp, + strand From VEGA annotation of GRCm38   64020 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9697  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Baiap2

Human homologs

Human Homolog		BAIAP2, BAI1-associated protein 2
NCBI Gene ID		10458
neXtProt AC		NX_Q9UQB8
Human Synonyms		BAP2, FLAF3, IRSP53
Human Chr (Location)		17q25; chr17:79008947-79091232 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(2) Gene trapped(7)
 

Homozygous mice show enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	actin filament bundle assembly, dendrite development, ...
Component	actin cytoskeleton, cell junction, ...
Function	cytoskeletal adaptor activity, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (79)    Tissues (45)    Images (34)
Theiler Stages: 19, 20, 23, 28

Assay Type	Results
RNA in situ	76
RT-PCR	3

cDNA source data(114)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(115) cDNA(114) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000004049 (Evidence)
Ensembl Gene Model	ENSMUSG00000025372 (Evidence)
Entrez Gene	108100 (Evidence)
UniGene	197534
DFCI	TC1573195, TC1579861, TC1592503, TC1595551, TC1724213
DoTS	DT.101349137, DT.101386906, DT.101707294, DT.91343408, DT.94299066, DT.97341455, DT.99866458
NIA Mouse Gene Index	U013649
Consensus CDS Project	CCDS25722.1, CCDS25723.1, CCDS25724.1
International Mouse Knockout Project Status	Baiap2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004049	VEGA Gene Model | MGI Sequence Detail	64020	C57BL/6J
transcript	OTTMUST00000009018	VEGA | MGI Sequence Detail	2394	Not Applicable
polypeptide	OTTMUSP00000004381	VEGA | MGI Sequence Detail	535	Not Applicable

All sequences(78) RefSeq(6) UniProt(6)

Polymorphisms

SNPs(101 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013606	IRSp53/MIM homology domain (IMD)
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
Protein Ontology	PR:000004632	brain-specific angiogenesis inhibitor 1-associated protein 2

References

(Earliest) J:62164 Fujiwara T, et al., Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. Biochem Biophys Res Commun. 2000 May 19;271(3):626-9
(Latest) J:184110 Verpelli C, et al., Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem. 2011 Oct 7;286(40):34839-50
All references(48)

Other accession IDs

MGI:2144701