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Hapln2
Gene Detail
Symbol

Name
ID
Hapln2
hyaluronan and proteoglycan link protein 2
MGI:2137300
Synonyms
4930401E20Rik, Bral1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
38.78 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:88021750-88027583 bp, - strand
From VEGA annotation of GRCm38

  5834 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11045  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hapln2

Human
homologs
Human Homolog HAPLN2, hyaluronan and proteoglycan link protein 2
NCBI Gene ID 60484
neXtProt AC  NX_Q9GZV7
Human Synonyms  BRAL1
Human Chr (Location)  1q23.1; chr1:156619294-156625725 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display reduced nerve conduction velocity and abnormalities in the neuronal extracellular matrix.
 
Interactions
Hapln2 interacts with 46 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell adhesion, establishment of blood-nerve barrier, ...
Component extracellular matrix, extracellular region, ...
Function hyaluronic acid binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 8
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(12)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000027207 (Evidence)
Ensembl Gene ModelENSMUSG00000004894 (Evidence)
Entrez Gene73940 (Evidence)
UniGene294467
DFCITC1583026, TC1602315, TC1615036
DoTSDT.486864, DT.97409690
NIA Mouse Gene IndexU024240
Consensus CDS ProjectCCDS17463.1
International Mouse Knockout Project StatusHapln2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027207 VEGA Gene Model | MGI Sequence Detail 5834 C57BL/6J ±  kb
transcript OTTMUST00000067275 VEGA | MGI Sequence Detail 1711 Not Applicable 
polypeptide OTTMUSP00000033820 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
InterPro IPR000538 Link
Protein Ontology PR:000008445 hyaluronan and proteoglycan link protein 2
References
(Earliest) J:70302 Hirakawa S, et al., The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. Biochem Biophys Res Commun. 2000 Oct 5;276(3):982-9
(Latest) J:197981 Susuki K, et al., Three mechanisms assemble central nervous system nodes of Ranvier. Neuron. 2013 May 8;78(3):469-82
All references(34)
Other
accession IDs
MGI:1921190

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory