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Hapln2 Gene Detail
Summary
  • Symbol
    Hapln2
  • Name
    hyaluronan and proteoglycan link protein 2
  • Synonyms
    4930401E20Rik, Bral1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137300
    NCBI Gene: 73940
  • Gene Overview
    MyGene.info: HAPLN2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88021750-88027583 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.78 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137300
protein coding gene Chr3:88020558-88027583 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027379
protein coding gene Chr3:88157920-88163747 (-)
A/J MGP_AJ_G0027343
protein coding gene Chr3:85166201-85172033 (-)
AKR/J MGP_AKRJ_G0027309
protein coding gene Chr3:87260254-87266090 (-)
BALB/cJ MGP_BALBcJ_G0027352
protein coding gene Chr3:85259897-85265729 (-)
C3H/HeJ MGP_C3HHeJ_G0027095
protein coding gene Chr3:87541811-87547643 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027798
protein coding gene Chr3:91404269-91410102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025151
protein coding gene Chr3:80797642-80803718 (-)
CAST/EiJ MGP_CASTEiJ_G0026541
protein coding gene Chr3:87746266-87752086 (-)
CBA/J MGP_CBAJ_G0027070
protein coding gene Chr3:94497581-94503411 (-)
DBA/2J MGP_DBA2J_G0027206
protein coding gene Chr3:84656456-84662290 (-)
FVB/NJ MGP_FVBNJ_G0027175
protein coding gene Chr3:82930792-82936611 (-)
LP/J MGP_LPJ_G0027314
protein coding gene Chr3:89127822-89133649 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027194
protein coding gene Chr3:100753513-100759327 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027856
protein coding gene Chr3:87016008-87021820 (-)
PWK/PhJ MGP_PWKPhJ_G0026274
protein coding gene Chr3:84452322-84458198 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026092
protein coding gene Chr3:86201033-86206476 (-)
WSB/EiJ MGP_WSBEiJ_G0026621
protein coding gene Chr3:87373959-87379817 (-)



Homology
more
  • Human Ortholog
    HAPLN2, hyaluronan and proteoglycan link protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HAPLN2, hyaluronan and proteoglycan link protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRAL1
  • Links
    NCBI Gene ID: 60484
    neXtProt AC: NX_Q9GZV7
    UniProt: Q9GZV7

  • Chr Location
    1q23.1; chr1:156601504-156626608 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11045
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HAPLN2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced nerve conduction velocity and abnormalities in the neuronal extracellular matrix.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004894 Ensembl Gene Model | MGI Sequence Detail 5834 C57BL/6J ±  kb
    transcript ENSMUST00000005014 Ensembl | MGI Sequence Detail 1711 Not Applicable  
    polypeptide ENSMUSP00000005014 Ensembl | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 13

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:1921190
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:70302 Hirakawa S, et al., The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. Biochem Biophys Res Commun. 2000 Oct 5;276(3):982-9
    • Latest
      J:197981 Susuki K, et al., Three mechanisms assemble central nervous system nodes of Ranvier. Neuron. 2013 May 8;78(3):469-82

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory