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Eefsec Gene Detail
Summary
  • Symbol
    Eefsec
  • Name
    eukaryotic elongation factor, selenocysteine-tRNA-specific
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137092
    NCBI Gene: 65967
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:88257334-88446539 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 39.32 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    684 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137092
protein coding gene Chr6:88257334-88446561 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031009
protein coding gene Chr6:89643754-89844271 (-)
A/J MGP_AJ_G0030975
protein coding gene Chr6:86191633-86386560 (-)
AKR/J MGP_AKRJ_G0030906
protein coding gene Chr6:88678267-88873873 (-)
BALB/cJ MGP_BALBcJ_G0030988
protein coding gene Chr6:86188967-86382228 (-)
C3H/HeJ MGP_C3HHeJ_G0030722
protein coding gene Chr6:95581658-95781818 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031445
protein coding gene Chr6:92070025-92269379 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028627
protein coding gene Chr6:84354308-84546197 (-)
CAST/EiJ MGP_CASTEiJ_G0030097
protein coding gene Chr6:88767397-88970243 (-)
CBA/J MGP_CBAJ_G0030672
protein coding gene Chr6:95608684-95811876 (-)
DBA/2J MGP_DBA2J_G0030828
protein coding gene Chr6:85485287-85676159 (-)
FVB/NJ MGP_FVBNJ_G0030781
protein coding gene Chr6:84676784-84868441 (-)
LP/J MGP_LPJ_G0030905
protein coding gene Chr6:89683251-89882440 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030814
protein coding gene Chr6:99718482-99916857 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031472
protein coding gene Chr6:88530719-88729255 (-)
PWK/PhJ MGP_PWKPhJ_G0029812
protein coding gene Chr6:84457569-84651043 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029640
protein coding gene Chr6:87342177-87537275 (-)
WSB/EiJ MGP_WSBEiJ_G0030178
protein coding gene Chr6:88982090-89178309 (-)



Homology
more
  • Human Ortholog
    EEFSEC, eukaryotic elongation factor, selenocysteine-tRNA specific
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EEFSEC, eukaryotic elongation factor, selenocysteine-tRNA specific
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EFSEC, SELB
  • Links
    NCBI Gene ID: 60678
    neXtProt AC: NX_P57772
    UniProt: P57772

  • Chr Location
    3q21.3; chr3:128153456-128426193 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033216 Ensembl Gene Model | MGI Sequence Detail 189206 C57BL/6J ±  kb
transcript ENSMUST00000165242 Ensembl | MGI Sequence Detail 2679 Not Applicable  
polypeptide ENSMUSP00000131207 Ensembl | MGI Sequence Detail 583 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000006911 selenocysteine-specific elongation factor
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005225 Small GTP-binding protein domain
    IPR000795 Transcription factor, GTP-binding domain
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR009000 Translation protein, beta-barrel domain superfamily
Molecular
Reagents
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  • All nucleic 39
    cDNA 39

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:63958 Tujebajeva RM, et al., Decoding apparatus for eukaryotic selenocysteine insertion. EMBO Rep. 2000;1(2):158-163
  • Latest
    J:192960 Gonzalez-Flores JN, et al., The selenocysteine-specific elongation factor contains a novel and multi-functional domain. J Biol Chem. 2012 Nov 9;287(46):38936-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory