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Kdm5a
Gene Detail
 Symbol
Name
ID
Kdm5a
lysine (K)-specific demethylase 5A
MGI:2136980
Synonyms Jarid1a, MGC:11659, Rbbp2, RBP2
Feature Type protein coding gene
Genetic Map
Chromosome 6
56.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:120364124-120444574 bp, + strand
From VEGA annotation of GRCm38

  80451 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3419  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone H3 lysine 4 demethylase (Jumonji/ARID domain-containing protein)
Gene Tree: Kdm5a

Human
homologs
Human Homolog KDM5A, lysine (K)-specific demethylase 5A
NCBI Gene ID 5927
neXtProt AC  NX_P29375
Human Synonyms  RBBP2, RBBP-2, RBP2
Human Chr (Location)  12p11; chr12:280057-389455 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced body size, abnormal involuntary movement and quantitative changes in the hematopoietic stem cell and myeloid progenitor compartments, consistent with enhanced survival and increased cycling. Neonatal survival is sensitive to genetic background.
 
Interactions
Kdm5a interacts with 491 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process chromatin modification, circadian regulation of gene expression, ...
Component cyclin-dependent protein kinase activating kinase holoenzyme complex, cytoplasm, ...
Function 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, C-19 gibberellin 2-beta-dioxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (104)    Tissues (69)    Images (18)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 22, 23, 24, 27, 28
Assay TypeResults
RNA in situ 96
RT-PCR 8
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(30) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023926 (Evidence)
Ensembl Gene ModelENSMUSG00000030180 (Evidence)
Entrez Gene214899 (Evidence)
NIA Mouse Gene IndexU007339
EC1.14.11.-
Consensus CDS ProjectCCDS51889.1
International Mouse Knockout Project StatusKdm5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023926 VEGA Gene Model | MGI Sequence Detail 80451 C57BL/6J ±  kb
transcript OTTMUST00000058459 VEGA | MGI Sequence Detail 10946 Not Applicable 
polypeptide OTTMUSP00000028321 VEGA | MGI Sequence Detail 1623 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001606 ARID/BRIGHT DNA-binding domain
InterPro IPR003347 JmjC domain
InterPro IPR013637 Lysine-specific demethylase-like domain
InterPro IPR003349 Transcription factor jumonji, JmjN
InterPro IPR004198 Zinc finger, C5HC2-type
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000009204 lysine-specific demethylase 5A
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:211833 Cao J, et al., Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep. 2014 Mar 13;6(5):868-77
All references(54)
Other
accession IDs
MGI:1353553, MGI:2141364

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory