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Tmem121b Gene Detail
Summary
  • Symbol
    Tmem121b
  • Name
    transmembrane protein 121B
  • Synonyms
    Cecr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136977
    NCBI Gene: 94047
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:120465900-120470768 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 56.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136977
 protein coding gene Chr6:120465900-120470907 (-)
129S1/SvImJ ENSMUSG00200045621
 protein coding gene Chr6:117666799-117671667 (-)
A/J ENSMUSG00195037813
 protein coding gene Chr6:117080893-117085761 (-)
AKR/J ENSMUSG00220026509
 protein coding gene Chr6:115966107-115970975 (-)
BALB/cJ ENSMUSG00180037213
 protein coding gene Chr6:117448547-117453415 (-)
C3H/HeJ ENSMUSG00175037620
 protein coding gene Chr6:60016869-60021738 (+)
C57BL/6NJ ENSMUSG00215047078
 protein coding gene Chr6:117432567-117437435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028803
 protein coding gene Chr6:115541462-115546274 (-)
CAST/EiJ ENSTCUG00005046466
 protein coding gene Chr6:117244221-117249045 (-)
CBA/J ENSMUSG00210042912
 protein coding gene Chr6:117215576-117220444 (-)
DBA/2J ENSMUSG00185046662
 protein coding gene Chr6:117870872-117875740 (-)
FVB/NJ ENSMUSG00205030581
 protein coding gene Chr6:116315346-116320214 (-)
JF1/MsJ ENSUMUG00000035234
 protein coding gene Chr6:116461190-116465974 (-)
LP/J ENSMUSG00230044585
 protein coding gene Chr6:119064187-119069055 (-)
NOD/ShiLtJ ENSMUSG00190038456
 protein coding gene Chr6:116828500-116833368 (-)
NZO/HlLtJ ENSMUSG00225046381
 protein coding gene Chr6:120956404-120961272 (-)
PWK/PhJ ENSLUMG00010043965
 protein coding gene Chr6:115816621-115821412 (-)
SPRET/EiJ ENSMSPG00010042488
 protein coding gene Chr6:118691063-118693421 (-)
WSB/EiJ ENSIUOG00005042192
 protein coding gene Chr6:117480790-117485658 (-)



Homology
more
  • Human Ortholog
    TMEM121B, transmembrane protein 121B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM121B, transmembrane protein 121B
  • Synonyms
    CECR6
  • Links
    NCBI Gene ID: 27439
    UniProt: Q9BXQ6

  • Chr Location
    22q11.1; chr22:17116297-17121367 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000094626 Ensembl Gene Model | MGI Sequence Detail 4869 C57BL/6J ±  kb
    transcript ENSMUST00000178687 Ensembl | MGI Sequence Detail 4869 Not Applicable  
    polypeptide ENSMUSP00000135924 Ensembl | MGI Sequence Detail 572 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141636, MGI:5908445
    References
    more
    • Summaries
      All 28
      Phenotypes 6
    • Earliest
      J:69774 Bruce SR, et al., Multiple features contribute to efficient constitutive splicing of an unusually large exon. Nucleic Acids Res. 2001 Jun 1;29(11):2292-302
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory